By Carrie Capili, Communications Specialist, Editor
The National Comprehensive Cancer Network® (NCCN®) Oncology Research Program (ORP) recently awarded research grants to investigators following a review of proposals submitted in response to the NCCN Ofatumumab Request for Proposals and the NCCN Pazopanib Request for Proposals. These grants were made possible through general research support of $4 million from GlaxoSmithKline.
"NCCN is pleased to announce that we will be funding five new ofatumumab research studies and seven pazopanib research studies in 2011, in addition to more than 50 active clinical and correlative trials that we are already supporting," commented Diane Paul, MS, RN, Vice President, ORP, NCCN. "Research grants enable NCCN and our member institutions to work with industry to help develop and bring scientific discoveries to market for the benefit of all patients. We are grateful for the opportunity to work with GlaxoSmithKline to make important strides in research possible."
The U.S. Food and Drug Administration (FDA) granted approval of ofatumumab (Arzerra®, GlaxoSmithKline) for the treatment of patients with chronic lymphocytic leukemia (CLL) refractory to fludarabine (Fludara®, Genzyme Corporation) and alemtuzumab (Campath®, Genzyme Corporation). In addition to CLL, the clinical trials at NCCN Member Institutions supported by the grant will further evaluate the therapy's effect in various lymphomas, including follicular, mantle cell, diffuse large B-cell, and non-Hodgkin's lymphomas.
The following proposals for ofatumumab have been awarded funding:
Pazopanib (Votrient™, GlaxoSmithKline) is currently approved by the FDA to treat patients with advanced renal cell carcinoma. The research grant to NCCN will evaluate the effectiveness of pazopanib in solid tumors, including sarcoma, thyroid, and neuroendocrine cancers.
The following proposals for pazopanib have been awarded funding:
The awardees responded to Requests for Proposals issued by the NCCN ORP to the 21 NCCN Member Institutions. Submissions were peer reviewed by the NCCN Ofatumumab Scientific Review Committee and the NCCN Pazopanib Scientific Review Committee. The awardees were selected based on several key components, including scientific merit, existing data, and the types of studies necessary to further evaluate the activity of the drugs.
The NCCN Oncology Research Program (ORP) draws on the expertise of investigators at NCCN Member Institutions to facilitate all phases of clinical research. This research is made possible by collaborations with pharmaceutical and biotechnology companies in order to advance therapeutic options for patients with cancer. The NCCN ORP will utilize the grant from GlaxoSmithKline to support investigator-initiated clinical and correlative studies at its NCCN Member Institutions for ofatumumab and pazopanib. To date, this successful research model has received more than $34 million in research grants and provided 87 investigators with funding for clinical and correlative trials that have produced numerous publications in peer-reviewed journals.