National Comprehensive Cancer Network

About NCCN

NCCN Updates Central Nervous System Cancers Guidelines

JENKINTOWN, Pa., October 23, 2007 — The National Comprehensive Cancer Network (NCCN) announces important updates to the NCCN Central Nervous System (CNS) Cancers Guidelines. The NCCN Clinical Practice Guidelines in Oncology™ are widely recognized and applied as the standard of care in oncology in the United States in both the community and the academic practice settings.

The NCCN CNS panel revised the guidelines by providing radiation therapy dosing and new detailed recommendations for chemotherapy for specific brain cancers or metastatic sites. For example, patients with recurrent CNS metastases from breast cancer, CNS lymphoma, or carcinomatous/lymphomatous meningitis can be treated with a high-dose methotrexate regimen.

The NCCN CNS guidelines now include specific recommendations for brain imaging. These imaging results are used mainly to make treatment decisions. The most common use is to differentiate radiation necrosis from active tumor, which may prevent unnecessary surgery or other therapies.

NCCN Clinical Practice Guidelines in Oncology™ are developed and continually updated through an evidence-based process with explicit review of the scientific evidence by multidisciplinary panels of expert physicians from NCCN Member Institutions. The most recent version of this and all the guidelines are available free of charge at www.nccn.org.

For questions about NCCN or for interview information, please contact Megan Martin 215.690.0576.

About the National Comprehensive Cancer Network

The National Comprehensive Cancer Network (NCCN), a not-for-profit alliance of 21 of the world’s leading cancer centers, is dedicated to improving the quality and effectiveness of care provided to patients with cancer. Through the leadership and expertise of clinical professionals at NCCN Member Institutions, NCCN develops resources that present valuable information to the numerous stakeholders in the health care delivery system. As the arbiter of high-quality cancer care, NCCN promotes the importance of continuous quality improvement and recognizes the significance of creating clinical practice guidelines appropriate for use by patients, clinicians, and other health care decision-makers. The primary goal of all NCCN initiatives is to improve the quality, effectiveness, and efficiency of oncology practice so patients can live better lives. For more information, visit NCCN.org.

The NCCN Member Institutions are:

• City of Hope Comprehensive Cancer Center
• Dana-Farber/Brigham and Women’s Cancer Center
  Massachusetts General Hospital Cancer Center
• Duke Comprehensive Cancer Center
• Fox Chase Cancer Center
• Huntsman Cancer Institute at the University of Utah
• Fred Hutchinson Cancer Research Center / Seattle Cancer Care Alliance
• The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
• Robert H. Lurie Comprehensive Cancer Center of Northwestern University
• Memorial Sloan-Kettering Cancer Center
• H. Lee Moffitt Cancer Center & Research Institute
• The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute
• Roswell Park Cancer Institute
• Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine
• St. Jude Children's Research Hospital / University of Tennessee Cancer Institute
• Stanford Comprehensive Cancer Center
• University of Alabama at Birmingham Comprehensive Cancer Center
• UCSF Helen Diller Family Comprehensive Cancer Center
• University of Michigan Comprehensive Cancer Center
• UNMC Eppley Cancer Center at The Nebraska Medical Center
• The University of Texas M. D. Anderson Cancer Center
• Vanderbilt-Ingram Cancer Center