National Comprehensive Cancer Network
NCCN Oncology Research Program (ORP)
NCCN ORP Affiliate Research Project
NCCN ORP Scientific Publications
NCCN ORP Investigator Steering Committee
NCCN Clinical Trials at NCCN Member Institutions
Find NCCN ORP Funded Clinical Trials at NCCN Member Institutions
NCCN Informed Consent Language Database
NCCN Specialized Imaging Research Consortium™ (SIRC)
NCCN ORP Disclosure Policy
NCCN Insights: Analytics, Research & Consulting
NCCN Collaboration with the National Business Group on Health
NCCN Health Information Technology Licensees
NCCN Research & Business Resources
Learn more about clinical trials at this NCCN Member Institution.
City of Hope is a research and treatment center dedicated to the prevention, treatment and cure of cancer, diabetes and other life-threatening diseases. Our mission is to shorten the time from initial research idea to new treatment in order to quickly bring cures to patients.
From prevention, to screening, to treatment, to rehabilitation, City of Hope cares for patients with expertise in numerous diseases and an array of world-class technologies and services.
- Brain Tumors
- Breast Cancer
- Gastrointestinal Cancers
- Gynecological Cancers
- Head and Neck Cancers
- Hematopoietic Cell Transplantation
- Lung and Thoracic Cancers
- Multiple Myeloma
- Musculoskeletal Cancers
- Pediatric Cancers
- Pituitary Tumors
- Prostate Cancer
- Skin Cancer
- Spine Tumors
- Thyroid Cancer
- Urology and Urologic Cancers
Since its founding in 1913, City of Hope has achieved numerous scientific breakthroughs and pioneered many lifesaving procedures that have benefited patients worldwide.
Below are the latest facts about this institution:
- City of Hope is one of 40 comprehensive cancer centers, the highest designation bestowed by the National Cancer Institute (NCI) and recognition of excellence in cancer treatment, research, prevention and education.
- City of Hope is a founding member of the National Comprehensive Cancer Network (NCCN), an alliance of the 23 leading cancer centers that defines and sets standards for cancer care nationally. City of Hope maintains the No. 1 hematology, prostate cancer and breast cancer programs in California, based on the number of patients treated. (Source: Office of Statewide Health Planning and Development)
- City of Hope was awarded more than $77.8 million in research grants and received more than $200 million in revenues from patented technologies in Fiscal Year 2011.
Research and Treatment Milestones
- Numerous breakthrough cancer drugs, including Herceptin, Rituxan, Avastin and Erbitux, are based on technology pioneered by City of Hope and are saving lives worldwide.
- Millions of people with diabetes worldwide benefit from synthetic human insulin developed through research conducted at City of Hope.
- City of Hope surgeons performed more robotic urologic procedures than any other institution in the nation.
- A pioneer in bone marrow transplantation, City of Hope has performed more than 10,600 bone marrow and stem cell transplants and operates one of the largest, most successful programs of its kind in the world. In addition, patients who underwent unrelated donor bone marrow and stem cell transplants at City of Hope have significantly better outcomes than expected under national standards, according to data from the National Marrow Donor Program.
Recent Research Breakthroughs
- Improving early detection of prostate cancer
City of Hope investigators are working to determine whether expressed prostate secretions (EPS) can be examined to rule out prostate cancer in patients. These studies use molecular biology to identify if cancer cells are present in EPS. Researchers hope to develop a noninvasive tool that may eventually eliminate the need for invasive prostate cancer testing such as a biopsy.
- Cancer and "superfoods"
City of Hope scientists have found that blueberries have the ability to control tumor growth, decrease metastasis and induce cell death in triple-negative breast cancer cells in the laboratory. Scientists led by Shiuan Chen, Ph.D., observed that blueberries help fight these cancers by suppressing pathways critical to tumor development and migration. The research team is planning human clinical trials to test blueberries' effect on breast cancer, in addition to research on the anti-cancer properties of other fruits, including pomegranates, and vegetables.
- New method of targeting AIDS virus
City of Hope scientists have developed a new method of targeting the AIDS virus that may provide a powerful one-two punch against HIV infection. Researchers developed a small piece of genetic material — called an RNA aptamer — that both interferes with HIV's ability to infect cells and acts as a delivery vehicle for another anti-HIV molecule.
Current anti-viral therapies can slow the progression of HIV infection and stave off disease, but the drugs often have toxic side effects. Moreover, HIV can develop resistance to the drugs. City of Hope researchers have been working on alternative ways of disrupting the HIV life cycle and stopping the virus in its tracks. New therapies could improve HIVpositive patients' chances of overcoming the infection.
- Easing side effects of bone marrow transplantation
Patients undergoing bone marrow transplantation (BMT) face more than just the challenges of their disease; they also must withstand the rigors of treatment. City of Hope researchers are pursuing a high-tech form of highly targeted radiation therapy that may ease side effects and allow more patients to benefit from BMT.
BMT aims to replace diseased cells in a patient's bone marrow with healthy blood stem cells. But physicians first must use high-dose chemotherapy — with or without radiation therapy — to destroy the patient's diseased marrow. Radiation therapy usually comes in the form of total body irradiation, or TBI, which can cause significant side effects.
City of Hope researchers were the first to explore total marrow irradiation, or TMI, as a replacement for TBI. TMI uses an advanced method of delivering radiation called TomoTherapy, allowing physicians to focus radiation beams on diseased bone marrow while avoiding exposure to healthy tissue. Researchers hope this targeted approach will lessen side effects while allowing for higher doses of therapeutic radiation.
- Training genetic counselors worldwide
City of Hope's Division of Clinical Cancer Genetics is a national leader in understanding the genetic roots that contribute to cancer risk, as well as identifying medical and lifestyle changes that can mitigate those risks. Genetic profiling may indicate a patient's disease risk, but counseling enables patients to make educated decisions. Through a grant from the National Cancer Institute, City of Hope provides training to community hospitals around the world to establish genetic counseling programs. To date, more than 245 clinicians from 45 states and 10 countries have completed the training program.
- Survivorship and support
Life after cancer treatment can present both physical and emotional challenges. City of Hope's Center for Cancer Survivorship provides long-term follow-up to create a bridge between cancer treatment and ongoing care.
The center provides specialized follow-up care and patient education in a clinical research setting. Current programs serve pediatric, prostate and breast cancer survivors.
- City of Hope has a unique model for rapidly translating innovations from the research lab to the clinical setting. The Center for Biomedicine & Genetics (CBG) allows physicians and scientists the freedom to test and refine the most promising new therapeu tics. Recognized as one of the nation's premier academic biologic manufacturing facilities, the CBG provides the isolation, environmental control and security needed for the manufacture of products for human use.
- A complementary manufacturing facility opens at City of Hope in 2012. The Chemical GMP Synthesis Facility will produce synthetic molecules according to good manufacturing practice standards set by the U.S. Food and Drug Administration. The facility's goal is to speed new therapies from the laboratory to clinical trials — beginning with an anti-cancer agent called COH-29 that was developed at City of Hope.
How City of Hope Adds Up -
- City of Hope is ranked as one of "America's Best Hospitals" in cancer and urology by U.S.News & World Report.
- City of Hope received full accreditation by the Joint Commission, the nation's most widely recognized health care accrediting body.
- City of Hope received two grants totaling $32.5 million from the California Institute for Regenerative Medicine. The first grant is for research into tumor-targeting stem cells that deliver cancer-killing agents right to brain tumors. The second grant is for research into an AIDS-related lymphoma therapy that may provide patients with permanent immunity to HIV.
- The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded City of Hope an $8.6 million contract to facilitate stem cell research from laboratory to clinical study. The five-year contract is the first from the NHLBI to focus on development and manufacturing of stem cell therapies.
- Forbes, The Chronicle of Philanthropy and The Nonprofit Times all featured City of Hope in their annual surveys of the nation's top nonprofit organizations.