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City of Hope Comprehensive Cancer Center
Duarte, CA (Los Angeles)

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City of Hope is an independent, biomedical research institution and comprehensive cancer center committed to researching, treating and preventing cancer, with an equal commitment to curing and preventing diabetes and other life-threatening diseases. Our mission is to transform the future of health by turning science into practical benefit and hope into reality.

From prevention, to screening, to treatment, to rehabilitation, City of Hope cares for patients with expertise in numerous diseases and an array of world-class technologies and services.

  • Brain Tumors
  • Breast Cancer
  • Gastrointestinal Cancers
  • Gynecological Cancers
  • Head and Neck Cancers
  • Hematopoietic Cell Transplantation
  • Leukemia
  • Lung and Thoracic Cancers
  • Lymphoma
  • Multiple Myeloma
  • Musculoskeletal Cancers
  • Pediatric Cancers
  • Pituitary Tumors
  • Prostate Cancer
  • Skin Cancer
  • Spine Tumors
  • Thyroid Cancer
  • Urology and Urologic Cancers

Institutional Distinctions

  • City of Hope is one of only 45 comprehensive cancer centers in the nation, the highest designation possible from the National Cancer Institute.
  • City of Hope is a founding member of the National Comprehensive Cancer Network, meaning our research and treatment protocols advance care throughout the nation.
  • In the 2014 fiscal year, City of Hope was awarded more than $72.9 million in research grants and received approximately $249.8 million in revenues from patented technologies.

A record of innovation

  • Numerous breakthrough cancer drugs, including Herceptin, Rituxan and Avastin, are based on technology pioneered at City of Hope and are now saving lives worldwide.
  • Millions of people with diabetes benefit from synthetic human insulin, developed through research conducted at City of Hope.
  • To date, City of Hope surgeons have performed over 10,000 robotic procedures for prostate, kidney, colon, liver, bladder, gynecologic, oral and other cancers.
  • City of Hope was a pioneer in bone marrow and stem cell transplants – and our program is now one of the largest, most successful programs of its kind. We’ve performed more than 12,000 bone marrow and stem cell transplants, with survival rates that are unparalleled.

Patient-and family-centered care

  • City of Hope is committed to expanding access to its uniquely patient- and family-focused care, its academic-level medical treatments and its visionary translational research.
  • Because life after cancer treatment can present both physical and emotional challenges, City of Hope creates a bridge between treatment and ongoing support. The Center for Cancer Survivorship provides specialized follow-up care and education for survivors of pediatric, prostate and breast cancers. The resulting research is helping physicians understand the long-term effects of cancer and its treatment — influencing how care is delivered today.
  • Patients – and their families – are our priority. In national surveys, City of Hope repeatedly scores in the highest percentiles for inpatient satisfaction.

Science that is saving lives

  • City of Hope researchers are investigating ways to harness the body’s natural defenses to fight cancer, an approach known as “immunotherapy.” 
    • One approach strikes a dual blow — shutting off a gene that promotes cancer while stimulating the immune system to action — in an effort to fight lymphoma and melanoma as well as brain, ovarian and prostate cancers.
    • Other studies are focused on engaging every stage of the immune response to defeat breast cancer.
  • City of Hope scientists studying “superfoods” have found that an extract of white button mushrooms can help block hormones that cause breast cancer and prostate cancer to grow and spread. They’re also researching the anti-cancer properties of other “superfoods” such as blueberries, pomegranates and grape seed extract.
  • City of Hope scientists pioneered the application of blood stem cell transplants to treat patients with HIV- and AIDS-related lymphoma. Our researchers used a new form of gene therapy to achieve the first long-term persistence of anti-HIV genes in patients with AIDS-related lymphoma. This treatment ultimately may cure not only lymphoma, but also HIV/AIDS, and our researchers are now expanding their studies with a new clinical trial.

Speed, efficiency and collaboration

  • Our research facilities set us apart. We have not one, but three, manufacturing facilities on campus that manufacture both biologic and chemical compounds to good manufacturing standards (GMP). This infrastructure helps us quickly turn breakthrough discoveries into life-saving therapies.
  • City of Hope holds more than 300 patents, and submits nearly 30 applications per year to the FDA for investigational new therapies. These numbers are exceptionally large for an organization of City of Hope’s size, reflecting our commitment to innovation and speeding treatments to patients.
  • City of Hope’s uniquely collaborative organization, our translational research model, and our research and manufacturing facilities were all designed and built to give doctors and researchers everything they need to turn science into powerful new treatments.

Training genetic counselors worldwide

  • City of Hope's Division of Clinical Cancer Genetics is a national leader in understanding the genetic roots that contribute to cancer risk, as well as identifying medical and lifestyle changes that can mitigate those risks. Genetic profiling may indicate a patient's disease risk, but counseling enables patients to make educated decisions. Through a grant from the National Cancer Institute, City of Hope provides training to community hospitals around the world to establish genetic counseling programs. To date, more than 245 clinicians from 45 states and 10 countries have completed the training program.