The major goals of Roswell Park Cancer Institute's Department of Pediatrics are to provide state-of-the-art treatment to children with malignant disorders, to conduct basic and clinical research aimed at improving cure rates and decreasing long-term toxicities, to identify and manage the acute and long-term complications of therapy, and to establish new and effective coping interventions for patients and their families. Over the years, Roswell Park Cancer Institute has pioneered many treatment innovations and cancer-related discoveries.

The pediatric oncologists have expertise in the management of all childhood cancers and are world-renowned experts in the areas listed below.

Special Expertise	� Brain Tumors � Long-Term Survivors � Lymphoma � Orthopedic Oncology � Stem Cell and Blood and Marrow Transplantation � Wilms Tumor

General Information

General Information Line	877.275.7724 (877.ASK.RPCI) Monday through Friday, 9:00 AM to 5:30 PM, EST. A voice mail system is available after hours and calls are returned the next business day.
International Calls (outside USA and Canada)	716.845.2300
Location	Buffalo, New York
Facilities Description	The campus has undergone a major modernization. This includes a brand-new inpatient unit and ambulatory care clinic, staffed by specialized nurses trained in pediatric oncology. Air handling has been designed to minimize risks of infection for immunocompromised patients.
Travel Assistance	Social workers provide assistance to patients and families in securing transportation and lodging. Patients and their families from RPCI use DoubleTree Club Hotel adjacent to the RPCI campus. The DoubleTree may be accessed from the first floor of RPCI's Basic Science building via an enclosed walkway. For information and reservations, call 716.845.0112. Their Web site is www.doubletree.Hilton.com/en/dt/hotels/index.jhtml?moreDesc=true&ctyhocn=BUFNYDT The Kevin Guest House, operated by volunteers, is the oldest hospitality house in the United States and the prototype for the 60 Ronald McDonald Houses across the country. The Kevin Guest House provides clean, safe, and peaceful living arrangements for families of patients receiving care at Roswell Park Cancer Institute. This is part of the National Association of Hospital Hospitality Houses. A Ronald McDonald House and a Hope Lodge are nearby.
Social Support	The Psychosocial Department offers support groups for pediatric patients and parents. All families are seen by a social worker and have on-going access to psychosocial support. A child-life specialist works with the children on the inpatient unit and the outpatient clinic.
Home Health Care	Several home care vendors are available to patients. The Essential Care Program provides psychosocial support to children with life-threatening illnesses in addition to their home care needs.
Ages Treated	Children from birth to age 21 are treated.

Clinical and Research Information

Chairman, Pediatric Oncology	Martin L. Brecher, MD
Multidisciplinary Teams	Each patient has a primary physician, nurse, and nurse practitioner that work with the patient throughout treatment and follow-up. A social worker, psychologist and child-life specialist are part of the team and work with patients and families as needed.
Cooperative Group Membership	Children's Oncology Group (COG)
Cooperative Group Activities	Participation in COG committees includes: � Hodgkin Lymphoma � Voting Body � Neuroscience � Central Nervous System � Pathology � Nominating � Late Effects � Adolescent Young Adult Oncologists are Principal Investigators on numerous studies.
Average Number of Pediatric Clinical Trials	76
Pediatric Clinical Trial Coordinator	Sandie Ciesla 716.845.4449

Research Efforts

Researchers at Roswell Park are studying the late effects of therapy for childhood cancer. Late organ toxicities and psychosocial adjustments in long-term survivors are being investigated. COG studies of the neuro-cognitive effects of treatment of acute lymphocytic leukemia states and of babies with brain tumors will be coordinated in Buffalo, as well as the biology study in pediatric Hodgkin lymphoma. Pediatric oncologists are involved in research to develop new targeted therapies and a vaccine for neuroblastoma.

Special Expertise

Brain Tumors

Treatment at the multidisciplinary brain tumor clinic includes investigational drug therapies, the use of stereotactic radiosurgery in selected cases, and long-term follow-up, including the management of late effects. Stereotactic radiation therapy enables a high dose of radiation to be delivered to a small, intracranial area without harming adjacent tissue.

Long-Term Survivors

Roswell Park Cancer Institute operates a Long-Term Follow-Up Clinic, created to provide specialized medical care and counseling to former childhood cancer patients. It was one of the first of its kind in the nation. Dramatic success in the treatment of childhood cancers has resulted in a population of survivors who may have unique problems, such as difficulty in finding employment, questions concerning their reproductive capability because of cancer and its treatment, and the possibility of developing other malignancies later in life. This Clinic assists cancer survivors in building full, productive lives.

Lymphoma

Investigators at Roswell Park Cancer Institute sit on the Hodgkin lymphoma core committee for the Children's Oncology Group (COG) and have chaired multiple institutional trials for Hodgkin lymphoma.

State-of-the-art diagnostic screening and cutting-edge therapies, including several immunotherapeutic trials (i.e., unlabeled and radiolabeled monoclonal antibody trials in the treatment of B-cell lymphomas), institutional and cooperative group (i.e., CALGB) trials, as well as standard and high-dose transplant therapies, are available.

Roswell Park Cancer Institute investigators piloted clinical trials in advanced small non-cleaved-cell lymphoma, which contributed to subsequent Children's Oncology Group (COG) multi-institutional trials. Survival for patients with advanced stage disease has improved significantly, with more than 70 percent of patients cured.

Orthopedic Oncology

Roswell Park Cancer Institute introduced a new surgical technique that saves the limbs of over 90 percent of soft tissue sarcoma patients whose options were once limited to amputation. The multidisciplinary team emphasizes limb-sparing procedures, new drug therapies, and rehabilitation.

Stem Cell and Blood and Marrow Transplantation

The Roswell Park BMT team utilizes allogeneic and autologous blood and marrow transplantation, stem cell infusion, and umbilical cord transplantation in the treatment of pediatric malignancies and bone marrow failure states.

Wilms Tumor

The National Wilms Tumor Study Group (NWTSG) was headquartered at Roswell Park Cancer Institute from 1990-2003, as a federally funded, multi-institutional cooperative group designed to study the biology and treatment of Wilms' tumor in children. The group involved the collaboration of a large number of pediatric surgeons, pediatric oncologists, pediatric radiation oncologists, pediatric urologists, and allied health professionals with a goal of developing more effective treatments for children with Wilms' tumor, as well as looking for the causes of this cancer. Due to therapeutic advances evaluated in NWTSG clinical trials, long-term survival rates for children with Wilms' Tumor increased from about 65 percent for patients diagnosed in 1970 to 90 percent for patients diagnosed in 1990. Survival reaches 95 percent for patients who have localized, completely resected disease of "favorable histology." The NWTSG has been incorporated into the Children's Oncology Group.

Statistics*

Percent of children treated in each age range

Age Range	0-1	2-5	6-12	13+
Percent Treated	5%	10%	65%	20%

Pediatric Oncology Program

No. of Inpatient Beds	No. of Oncologists/Related Specialists	No. of Admissions	Average Length of Stay (days)	No. of New Outpatients	Total Outpatient Visits	No. of Bone Marrow Transplants
24	19	512	3.7	54	3,694	6

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