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Updated Guidelines for Colon and Rectal Cancers

The NCCN Clinical Practice Guidelines in Oncology™ for Colon Cancer and for Rectal Cancer have been updated and published. Both Guidelines are now available in v.1.2010.

Several updates were made to the NCCN Guidelines for Colon Cancer and for Rectal Cancer based on BRAF gene status. Updates include a new section for BRAF testing added to the Principles of Pathologic Review. For patients with metastatic disease, consideration of tumor BRAF gene status was added to the workup recommendations as an option if KRAS is nonmutated. A new footnote was added stating that "Patients with a known V600E BRAF mutation appear to be unlikely to benefit from anti-EGFR monoclonal antibodies."