NCCN Guidelines for Patients® | Chronic Myelogenous Leukemia - page 15

15
NCCN Guidelines for Patients
®
: Chronic Myelogenous Leukemia
Version 1.2014
Definitions:
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See Part 1 on page
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The peripheral blood and bone marrow samples removed from your body are
sent to the lab for testing. At the lab, a pathologist will examine the samples with a
microscope and perform a number of different tests. A pathologist is a doctor who’s
an expert in testing cells and tissue for signs of disease. The blood sample will be
tested for signs of CML, such as too many white blood cells and abnormal levels of
certain chemicals in the blood. The bone marrow sample will be tested for signs of
CML such as the Philadelphia chromosome and the
BCR-ABL
gene. It usually takes
several days before the lab results are known. If you do not have the Philadelphia
chromosome or the
BCR-ABL
gene, then you do not have CML. The lab tests used
for CML are listed in Table 1 and are described on the following pages.
2.3 Lab tests
BCR-ABL
gene:
Abnormal
gene formed when the
BCR
and
ABL
genes join
Biopsy:
Removal of small
amounts of tissue for testing
Bone marrow:
Soft tissue
in the center of most bones
where blood cells are made
Chromosome:
Strand of
bundled instructions for
making and controlling cells
Gene:
Instructions for
making and controlling cells
Local anesthesia:
A loss
of feeling in a small area of
the body caused by drugs
Microscope:
A tool that
uses lenses to see things
the eyes can’t
Peripheral blood:
Blood
outside of the bone that
circulates in the body
Sedative:
Drug that helps
a person relax or go to
sleep
Table 1. Lab tests for CML
The test
Test sample
CBC (
c
omplete
b
lood
c
ount) with differential
Peripheral blood
Blood chemistry profile
Peripheral blood
Cytochemistry
Peripheral blood or bone marrow
HLA (
h
uman
l
eukocyte
a
ntigen) testing
Peripheral blood
Cell assessment
Peripheral blood or bone marrow
Bone marrow cytogenetics
Bone marrow
QPCR (
q
uantitative reverse transcriptase
p
olymerase
c
hain
r
eaction)
Peripheral blood or bone marrow
FISH (
f
luorescence
i
n
s
itu
h
ybridization)
Peripheral blood
Flow cytometry
Peripheral blood or bone marrow
BCR-ABL
gene mutation analysis
Peripheral blood or bone marrow
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