NCCN Guidelines for Patients® | Chronic Myelogenous Leukemia - page 25

NCCN Guidelines for Patients
: Chronic Myelogenous Leukemia
Version 1.2014
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A type of white
blood cell that helps fight
infections and has small
particles (granules)
Blast cell:
An immature
blood cell
Bone marrow:
The soft,
sponge-like tissue in the
center of most bones
where blood cells are made
A type of white
blood cell that helps fight
infections and has small
particles (granules)
Peripheral blood:
outside of the bone that
circulates throughout the
A type of blood
cell that helps control
An organ to the
left of the stomach that
helps protect the body from
3.4 Risk assessment
In addition to the phase of CML, other factors can affect and help predict the
likely outcome (prognosis) of CML treatment. These are called prognostic
factors. Prognostic scoring systems use these factors to determine a patient’s
risk score. Based on the risk score, patients are classified into risk groups—
low-, intermediate-, or high-risk. People in the same risk group are similar in
certain ways and will likely respond to certain treatments in the same way.
Therefore, doctors often use risk scores to help guide treatment decisions. In
general, a person classified as low-risk is more likely to have a better response
to treatment.
Sokal and Hasford are the two prognostic scoring systems used for patients
with CML. The Sokal score is based on your age, spleen size, platelet count,
and the percentage of blasts in the peripheral blood. In addition to these
four factors, the Hasford score also includes the number of eosinophils and
basophils in the peripheral blood.
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