NCCN Guidelines for Patients® | Colon Cancer - page 67

NCCN Guidelines for Patients
®
Colon Cancer, Version 1.2014
7
Treatment guide
Least toxic pathway
7.5 Least toxic pathways
Chart 7.5 The least toxic pathways
have
potentially the least harmful regimens. Infusional
5-FU/LV is an option. 5-FU has fewer severe side
effects when given by infusion rather than bolus.
Another option is to take capecitabine with or without
bevacizumab. If the
RAS
genes are normal, a third
option is to take panitumumab or cetuximab.
Initial treatment
Infusional 5-FU/LV or capecitabine ±
bevacizumab, or
If normal
KRAS
and
NRAS
genes:
– Cetuximab, or
– Panitumumab
65
Chart 7.5 Least toxic pathways
1...,57,58,59,60,61,62,63,64,65,66 68,69,70,71,72,73,74,75,76,77,...88
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