NCCN Guidelines for Patients® | Esophageal Cancer - page 75

75
NCCN Guidelines for Patients
®
: Esophageal Cancer
Version 1.2013
Part 6: Adenocarcinomas
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KPS (
K
arnofsky
P
erformance
S
tatus)
• A
score of 0 to 49
means you are unable to care for yourself.
• A
score of 50 to 79
means you are unable to work and some assistance
is needed.
• A
score of 80 to 100
means you are able to do your normal work
and activities.
You may be able to have chemotherapy if you have a ECOG score of 2 or less
or a KPS score of 60 more. Two back-to-back chemotherapy regimens are
recommended. Three regimens may be given if you are healthy enough and
have good performance status. If do have chemotherapy, it is important for your
doctors to assess for side effects on a regular basis.
First-line chemotherapy regimens are listed next. Trastuzumab is a targeted
therapy drug that is added to chemotherapy if the cancer cells have too
many HER2s. Read page 25 for more information on HER2 status. If you are
given a 5-FU regimen, leucovorin may be added to limit side effects of the
chemotherapy. If the cancer doesn’t respond to first-line regimens, your doctor
may give you a second-line regimen. Alternative regimens may be used with
first- or second-line regimens.
Definitions:
dysphagia:
Difficult or
painful swallowing
side effect:
An unhealthy
or unpleasant physical
or emotional response to
treatment
!
Read pages 28–38
for information on
cancer treatments.
Acronyms:
HER2
= human epidermal
growth factor receptor 2
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