NCCN Guidelines for Patients® | Melanoma - page 47

NCCN Guidelines for Patients
: Melanoma
Version 1.2013
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Severe tiredness
despite getting enough
sleep that limits one’s
ability to function
A clear fluid
containing white blood
cells that fight infection and
Lymph node dissection:
Surgery to remove some
or all groups of special
disease-fighting cells from
the area near the tumor
Sentinel lymph node
Surgery to remove
the first group of special
disease-fighting cells
(lymph node) to which
cancer cells travel after
leaving the primary tumor
See Part 4 on
page 34 for more
treatment details
and definitions.
Part 5: Treatment side effects
Immunotherapy side effects
Like chemotherapy, side effects of immunotherapy depend on the drug, how it
is given, the amount taken, the length of treatment, and the person. When given
in high doses, some immunotherapy drugs can cause very serious side effects.
Some side effects listed below are caused only by one immunotherapy drug.
Common side effects of immunotherapy for melanoma include:
• Fever,
• Chills,
• Aches,
• Fatigue,
• Skin rash and itching,
• Diarrhea,
• Low blood pressure,
• Heart damage,
• Liver damage, and
• Fluid buildup.
Targeted therapy side effects
Side effects of targeted therapy depend on the drug, dose, length of treatment,
and the person. Some side effects listed below are caused only by one targeted
drug. Others are caused by both targeted drugs but differ in how likely they are
to occur. Common side effects of targeted drugs for melanoma include:
• Joint and/or muscle pain,
• Fatigue,
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