NCCN Guidelines for Patients
Melanoma, Version 1.2014
The “building blocks” of tissues in the body.
central nervous system (CNS)
The brain and spinal cord.
Drugs that kill fast-growing cells, including normal cells and
A scale of tumor depth with 5 scores based on which layer of
skin the tumor has grown into.
A rating of the extent of melanoma in the body based on
the physical exam, imaging tests, and biopsy of the first
(primary) melanoma tumor.
Research on a test or treatment to assess its safety or how
well it works.
The use of two or more drugs.
computed tomography (CT) scan
A test that uses x-rays from many angles to make a picture
of the inside of the body.
Supporting and binding tissue that surrounds other tissues
A dye put into your body to make clearer pictures during
imaging tests (tests that take pictures of the inside of the
Substances made in the body that boost or activate the
immune system (the body’s natural defense against
disease). Cytokines can also be made in a lab.
deep margin status
Presence or absence of cancer cells in the normal-looking
tissue under a tumor removed during surgery.
dermal mitotic rate
A measure of how many cancer cells are actually growing
A doctor who’s an expert in diseases of the skin.
A doctor who’s an expert in testing skin cells and tissues for
The second layer of skin that is beneath the top layer
A melanoma tumor with dense connective tissue.
Identification of a disease.
Bigger in size than normal.
The outer layer of skin.
Removal by surgery.
Surgery that removes the entire skin tumor or abnormal-
looking area (lesion) to test for cancer cells.
excisional lymph node biopsy
Surgery that removes the entire enlarged lymph node(s)
through a surgical cut in the skin to test for cancer cells.
external beam radiation therapy
Radiation therapy (use of high-energy rays to destroy cancer
cells) received from a machine outside the body.
Severe tiredness despite getting enough sleep that limits
one’s ability to function.
fine-needle aspiration (FNA) biopsy
Use of a thin needle to remove fluid or tissue from the body
to be tested for disease.
Tests done after treatment to check for signs of cancer return
(recurrence) or spread (metastasis).
A set of coded instructions in cells for making new cells and
controlling how cells behave.