NCCN Guidelines for Patients® | Multiple Myeloma - page 42

NCCN Guidelines for Patients
Multiple Myeloma, Version 1.2014
Treatment guide
Multiple myeloma testing
4.1 Multiple myeloma testing
Chart 4.1
shows the initial tests that are
recommended when your doctor thinks you may have
multiple myeloma. These tests are used to confirm
(diagnose) myeloma and to assess if the cancer is
causing symptoms. For full details on each test, see
Part 2 on page 14.
The first list of tests in the chart above includes the
initial tests that are recommended for everyone. The
second list includes the tests that may be useful for
some people, in addition to the other initial tests.
Initial tests for diagnosis
With your medical history and a physical exam,
your doctor can assess if you’re having myeloma
symptoms, such as fatigue or bruising. Bone damage
may be seen with a bone survey. Some blood tests
are also used to assess for symptoms of myeloma. A
CBC will show if the number of blood cells is low for
each blood cell type. A blood chemistry test checks
if certain substances in your blood are too low or too
high. It measures BUN, electrolytes, and creatinine
levels to check if your kidneys are working properly.
Chart 4.1 Tests for multiple myeloma
Initial tests for diagnosis
Possible other tests
• Medical history and physical exam
Imaging tests
• Bone survey
Blood tests
• Blood chemistry: BUN, creatinine, electrolytes,
LDH, albumin, calcium, beta-2 microglobulin
• Serum free light chain assay
• Serum quantitative immunoglobulins
Urine tests
• Total protein
Bone marrow tests
• Bone marrow aspiration and biopsy
• Immunohistochemistry and/or multiparameter
flow cytometry
• Genetic tests
Imaging tests
• CT scan without contrast
• PET/CT scan
• Bone densitometry
Tissue tests
• Tissue biopsy for solitary plasmacytoma
• Staining of marrow and fat pad for
amyloid protein
• Plasma cell labeling index
Blood tests
• Serum viscosity
• HLA typing
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