NCCN Guidelines for Patients® | Multiple Myeloma - page 47

45
NCCN Guidelines for Patients
®
Multiple Myeloma, Version 1.2014
4
Treatment guide
Measuring treatment response
Complete response
No
M-proteins
in the blood or urine, less than
5 out of 100 cells in the
bone marrow
are
plasma cells
, and no increase in the size or
number of
bone lesions
.
Partial response
The amount of M-proteins in the blood has
decreased by half or more, the amount of
M-proteins in the urine has decreased by 90%
or more, and there’s no increase in size or
number of bone lesions.
Stable disease
Cancer tests show no signs of response and
no signs of decline.
Progressive disease
One or more of the following has occurred:
at least a 25% increase in the amount of
M-proteins in the blood and urine, a 25%
increase in the number of plasma cells in the
bone marrow, an increase in size or number
of bone lesions, or an increase in
calcium
levels not explained by other conditions.
Clinical relapse
One or more of the following has occurred:
there are direct signs of cancer growth, signs
of organ damage, an increase in the number
or size (at least 50% larger) of
plasmacytomas
or bone lesions, increased calcium levels,
an increase in
creatine
levels in blood, or a
decrease in the number of
red blood cells
.
Relapse from complete response
One or more of the following has occurred:
a return of M-proteins in blood or urine, 5 or
more out of 100 cells in the bone marrow are
plasma cells, there are new or enlarging bone
lesions, or there are high calcium levels not
explained by other conditions.
Measuring treatment response
A treatment response is an outcome or
improvement related to treatment. The treatment
response is defined by how well systemic
therapy is killing myeloma cells and the severity
of symptoms. The treatment response will
fall into one of the six groups listed below.
“Complete” and “partial” responses are often
jointly referred to as “response.”
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