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National Comprehensive Cancer Network

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NCCN Flash Updates: NCCN Guidelines® and NCCN Compendium® Updated for Prostate Cancer

NCCN has published updates to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) and the NCCN Drugs and Biologics Compendium (NCCN Compendium®) for Prostate Cancer. These NCCN Guidelines® are currently available as Version 2.2020.

  • Systemic therapy for M1 CRPC: Adenocarcinoma (PROS-16 and PROS-16A)
    • Added olaparib for HRRm to the useful in certain circumstances treatment options under subsequent therapy as a category 1 recommendation with the following footnote: Olaparib is a treatment option for patients with mCRPC and a pathogenic mutation (germline and/or somatic) in a homologous recombination repair gene (BRCA1, BRCA2, ATM, BARD1, BRIP1, CDK12, CHEK1, CHEK2, FANCL, PALB2, RAD51B, RAD51C, RAD51D or RAD54L), who have been treated with androgen receptor-directed therapy. Patients with PPP2R2A mutations in the PROfound trial experienced an unfavorable risk-benefit profile. Therefore, olaparib is not recommended in patients with a PPP2R2A mutations (see Discussion).
    • Changed the Category of Evidence and Consensus for olaparib from a category 2B to a category 1 recommendation as a second-line treatment option post abiraterone/enzalutamide.
    • Added rucaparib for BRCAm to the useful in certain circumstances treatment options under second-line treatment and subsequent therapy as a category 2A recommendation with the following footnote: Rucaparib is a treatment option for patients with mCRPC and a pathogenic BRCA1 or BRCA2 mutation (germline and/or somatic) who have been treated with androgen receptor-directed therapy and a taxane-based chemotherapy. If the patient is not fit for chemotherapy, rucaparib can be considered even if taxane-based therapy has not been given.


Previous updates to the NCCN Guidelines for Prostate Cancer can be found in the UPDATES section of the current version.

 

For the complete updated versions of the NCCN Guidelines, NCCN Guidelines with NCCN Evidence Blocks™, the NCCN Drugs & Biologics Compendium (NCCN Compendium®), the NCCN Biomarkers Compendium®, the NCCN Chemotherapy Order Templates (NCCN Templates®), the NCCN Radiation Therapy Compendium™, and the NCCN Imaging Appropriate Use Criteria (NCCN Imaging AUC™), please visit NCCN.org.

To view the NCCN Guidelines for Patients®, please visit NCCN.org/patientguidelines.

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