National Comprehensive Cancer Network

About NCCN

UPDATES: NCCN Guidelines® and NCCN Compendium®

NCCN Flash Update distributed 10 October 2013

NCCN has published updates to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Penile Cancer. These NCCN Guidelines® are currently available as Version 1.2014.

  • Primary Evaluation (PN-1)
    • Imaging by “MRI or ultrasound” was removed.
  • Management of Bulky/Unresectable Inguinal Lymph Nodes (PN-5)
    • For positive “unilateral; mobile” nodes or “multiple or bilateral inguinal lymph nodes; mobile or fixed” confirmed by fine needle aspiration, “neoadjuvant chemotherapy” was added as a treatment option.
  • Principles of Chemotherapy
    • For second-line therapy, “irinotecan” was removed as a treatment option. (PN-C 1 of 2)
    • “Radiosensitizing agents and combinations (For radiotherapy with concurrent chemotherapy)” was separated into “preferred” and “alternate options.” (PN-C 2 of 2)
      • The preferred options are “cisplatin alone, or in combination with 5-FU” and the alternate options are “mitomycin C in combination with 5-FU” and “capecitabine.”
  • The Discussion section has been updated to reflect the changes in the algorithm. (MS-1)

For the complete updated versions of the NCCN Guidelines, NCCN Drugs & Biologics Compendium (NCCN Compendium®) , and the NCCN Chemotherapy Order Templates (NCCN Templates®), please visit

To access the NCCN Biomarkers Compendium™, please visit

To view the NCCN Guidelines for Patients®, please visit

Free NCCN Guidelines apps for iPad and Android tablets are now available! Visit