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NCCN Updates Cervical Cancer Guidelines

JENKINTOWN, Pa., August 1, 2007 — The National Comprehensive Cancer Network (NCCN) announces important updates to the NCCN Cervical Cancer Guidelines. The NCCN Clinical Practice Guidelines in Oncology™ are widely recognized and applied as the standard of care in oncology in the United States in both the community and the academic practice settings.

The cervical cancer guidelines have been updated to expand the indications for fertility-preserving surgery. Women with stage IB1 disease whose lesions are ≤ 2 centimeters are now candidates for radical trachelectomy. It is important to note that not all women with stage IB1 disease are eligible, only those with smaller lesions. Previously, only women with stage IA2 disease were candidates for radical trachelectomy.

Adjuvant treatment has been revised for some women with stages IA1-IIA disease who have had hysterectomy. For women with negative lymph nodes after surgery, pelvic RT is now a category 1 recommendation for those women with high-risk factors. These high-risk factors include large primary tumor, deep stromal invasion and/or lymphovascular space invasion.

Positron-emission tomography (PET) scan is no longer optional for ≥ stage IB2 disease and is now recommended as part of the workup.

NCCN Clinical Practice Guidelines in Oncology™ are developed and updated through an evidence-based process with explicit review of the scientific evidence by multidisciplinary panels of expert physicians from NCCN Member Institutions. The most recent version of this and all the guidelines are available free of charge at www.nccn.org.