Facebook Tracking Image

National Comprehensive Cancer Network

About NCCN

NCCN Awards Research Grants to Eight Investigators to Support Clinical and Pre-Clinical Studies of Mirvetuximab Soravtansine in Various Cancers

The NCCN Oncology Research Program has awarded research grants to eight investigators to study the effectiveness of mirvetuximab soravtansine in folate receptor alpha-positive cancers.

FORT WASHINGTON, PA — The National Comprehensive Cancer Network® (NCCN®) Oncology Research Program (ORP) has awarded eight grants to investigators to support clinical and pre-clinical studies of mirvetuximab soravtansine (IMGN853) and advance scientific knowledge of its uses in ovarian and other folate receptor alpha (FRα)-positive cancers.

“This is another of the exciting research projects targeting unique vulnerabilities of cancer cells identified through molecular characterization of cancers,” said Robert C. Young, MD, Interim Vice President, NCCN ORP. “We are grateful to ImmunoGen for their funding of these eight promising studies aimed at targeted therapy in cancers that affect millions of women worldwide.”

“We are pleased to provide this funding to NCCN ORP to support preclinical and clinical exploration of our FRα-targeted agent mirvetuximab soravtansine,” said Anna Berkenblit, MD, Vice President and Chief Medical Officer, ImmunoGen. “NCCN and its Member Institutions share in our mission to develop innovative therapies that meaningfully improve the lives of patients and this collaboration will help to further advance our understanding of the potential of mirvetuximab soravtansine.”

Mirvetuximab soravtansine (IMGN853) is a potential new treatment for cancers that highly express FRα, which include most cases of ovarian cancer and certain endometrial, breast, and lung cancers.  An antibody-drug conjugate (ADC), mirvetuximab soravtansine comprises an ImmunoGen FRα-targeting antibody attached to the company's potent tubulin-acting agent, DM4. The antibody serves to target the compound specifically to cancer cells expressing FRα, and the DM4 serves to kill these cells.1

The following clinical studies were awarded funding:

  • Kimberly Blackwell, MD, Duke Cancer Institute, “Determining the Clinical Efficacy and Predictive Biomarkers of Mirvetuximab Soravtansine (IMGN853) in Folate Receptor Alpha (FRA) Expressing, Chemotherapy Refractory Triple Negative Breast Cancer (TNBC)”
  • Mihaela Cristea, MD, City of Hope Comprehensive Cancer Center, “A Phase I, Dose Escalation Safety and Tolerability Study of Mirvetuximab Soravtansine and Gemcitabine in Patients with FRα Positive Recurrent Ovarian, Primary Peritoneal, Fallopian Tube, Endometrial, and Breast Cancer”
  • Stacey Moulder, MD, MSCI, The University of Texas MD Anderson Cancer Center, “Women’s Triple-Negative First-Line Study: A Phase II Trial of Mirvetuximab Soravtansine in Patients with Localized Triple-Negative Breast Cancer (TNBC) with Tumors Predicted Insensitive to Standard Neoadjuvant Chemotherapy (NACT), Including a Lead in Cohort to Establish Activity in Patients with Metastatic TNBC”

The following pre-clinical studies were awarded funding:

The awardees responded to a Request for Proposals issued by the ORP to the NCCN Member Institutions. Submissions were peer reviewed by the NCCN Mirvetuximab Soravtansine Scientific Review Committee. The funded concepts were selected based on several criteria, including scientific merit, existing data, and the types of studies necessary to further evaluate the efficacy of mirvetuximab soravtansine.

The NCCN ORP draws on the expertise of the investigators at the NCCN Member Institutions and their affiliates to facilitate all phases of clinical research. This research is made possible by collaborations with pharmaceutical and biotechnology companies in order to advance therapeutic options for patients with cancer.

For more information about NCCN ORP, visit NCCN.org/ORP.


1 Ab, Olga, et al. IMGN853, an anti-Folate Receptor I antibody-maytansinoid conjugate for targeted cancer therapy. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4576. doi:10.1158/1538-7445.AM2011-4576


About the National Comprehensive Cancer Network

The National Comprehensive Cancer Network® (NCCN®) is a not-for-profit alliance of 30 leading cancer centers devoted to patient care, research, and education. NCCN is dedicated to improving and facilitating quality, effective, efficient, and accessible cancer care so patients can live better lives. Through the leadership and expertise of clinical professionals at NCCN Member Institutions, NCCN develops resources that present valuable information to the numerous stakeholders in the health care delivery system. By defining and advancing high-quality cancer care, NCCN promotes the importance of continuous quality improvement and recognizes the significance of creating clinical practice guidelines appropriate for use by patients, clinicians, and other health care decision-makers around the world.

The NCCN Member Institutions are:

  • Abramson Cancer Center at the University of Pennsylvania
  • Fred & Pamela Buffett Cancer Center
  • Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute
  • City of Hope National Medical Center
  • Dana-Farber/Brigham and Women's Cancer Center | Massachusetts General Hospital Cancer Center
  • Duke Cancer Institute
  • Fox Chase Cancer Center
  • Huntsman Cancer Institute at the University of Utah
  • Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance
  • The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  • Robert H. Lurie Comprehensive Cancer Center of Northwestern University
  • Mayo Clinic Cancer Center
  • Memorial Sloan Kettering Cancer Center
  • Moffitt Cancer Center
  • The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute
  • O'Neal Comprehensive Cancer Center at UAB
  • Roswell Park Comprehensive Cancer Center
  • Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine
  • St. Jude Children's Research Hospital/The University of Tennessee Health Science Center
  • Stanford Cancer Institute
  • UC San Diego Moores Cancer Center
  • UCLA Jonsson Comprehensive Cancer Center
  • UCSF Helen Diller Family Comprehensive Cancer Center
  • University of Colorado Cancer Center
  • University of Michigan Rogel Cancer Center
  • The University of Texas MD Anderson Cancer Center
  • University of Wisconsin Carbone Cancer Center
  • UT Southwestern Simmons Comprehensive Cancer Center
  • Vanderbilt-Ingram Cancer Center
  • Yale Cancer Center/Smilow Cancer Hospital