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NCCN Flash Updates: NCCN Guidelines^® and NCCN Compendium^® Updated for B-Cell Lymphomas

NCCN has published updates to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines^®) and the NCCN Drugs & Biologics Compendium (NCCN Compendium^®) for B-Cell Lymphomas. These NCCN Guidelines^® are currently available as Version 4.2020.

• Follicular Lymphoma and Nodal Marginal Zone Lymphomas (FOLL-7, FOLL-8, NODE-5, NODE-6)
  • Histologic transformation to DLBCL
    • After minimal or no prior chemotherapy, if no response or progressive disease to chemoimmunotherapy, "Tafasitamab + lenalidomide (non-candidates for transplant)" was added as a category 2A recommendation.
    • After multiple lines of prior therapies, "Tafasitamab + lenalidomide (non-candidates for transplant)" was added as a category 2A recommendation.
    • Footnote was added, "It is unclear if tafasitamab will have a negative impact on the efficacy of subsequent anti-CD19 CAR T-cell therapy."
• Diffuse Large B-Cell Lymphoma (BCEL-C 2 of 4)
  • Second-line and Subsequent Therapy (non-candidates for transplant)
    • Other recommended regimen, "Tafasitamab + lenalidomide" was added as a category 2A recommendation. Footnote was added, "It is unclear if tafasitamab will have a negative impact on the efficacy of subsequent anti-CD19 CAR T-cell therapy."

NCCN has published updates to the following NCCN Guidelines with NCCN Evidence Blocks™:

• Small Cell Lung Cancer, Version 1.2021
• Soft Tissue Sarcoma, Version 2.2020

For the complete updated versions of the NCCN Guidelines, NCCN Guidelines with NCCN Evidence Blocks™, the NCCN Drugs & Biologics Compendium (NCCN Compendium^®), the NCCN Biomarkers Compendium^®, the NCCN Chemotherapy Order Templates (NCCN Templates^®), the NCCN Radiation Therapy Compendium™, and the NCCN Imaging Appropriate Use Criteria (NCCN Imaging AUC™), please visit NCCN.org.

To view the NCCN Guidelines for Patients^®, please visit NCCN.org/patientguidelines.

Free NCCN Guidelines apps for iPhone, iPad, and Android devices are now available! Visit NCCN.org/apps.

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