NCCN Flash Updates: NCCN Guidelines Updated for Soft Tissue Sarcoma

NCCN has published updates to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines^®), NCCN Radiation Therapy Compendium™, and the Drugs and Biologics Compendium (NCCN Compendium^®) for Soft Tissue Sarcoma. These NCCN Guidelines^® are currently available as Version 2.2022.

Link directly to the Updates section of the NCCN Guidelines: Soft Tissue Sarcoma

RETSARC-2

• RT modified: (consider for tumors at high risk for local recurrence) (if not previously given for the primary tumor).
• Footnote "j", modified: Consider systemic therapy if high risk for metastatic disease or if downstaging is needed to facilitate resection. and/or high risk for local recurrence. Systemic therapy is not recommended for low-grade tumors. (Also for RETSARC-3 and RETSARC-5).

SARC-E (3 of 4)

Neoadjuvant RT, modified:

• Neoadjuvant RT for retroperitoneal/intra-abdominal sarcomas can be considered in selected patients at high risk for local recurrence.
• If neoadjuvant RT is deemed to be appropriate for a patient, the following General dose guidelines are recommended....
  • The following reference is new: Bonvalot S, Gronchi A, Le Péchoux C, et al. Preoperative radiotherapy plus surgery versus surgery alone for patients with primary retroperitoneal sarcoma (EORTC-62092: STRASS): a multicentre, open-label, randomised, phase 3 trial Lancet Oncol 2020;21:1366-1377.

MS-1

• Sections of the Discussion have been updated to reflect the changes in the algorithm.

Previous updates to the NCCN Guidelines for Soft Tissue Sarcoma can be found in the UPDATES section of the current version.
 

For the complete updated versions of the NCCN Guidelines, NCCN Guidelines with NCCN Evidence Blocks™, the NCCN Drugs & Biologics Compendium (NCCN Compendium^®), the NCCN Biomarkers Compendium^®, the NCCN Chemotherapy Order Templates (NCCN Templates^®), the NCCN Radiation Therapy Compendium™, and the NCCN Imaging Appropriate Use Criteria (NCCN Imaging AUC™), please visit NCCN.org.

To view the NCCN Guidelines for Patients^®, please visit NCCN.org/patientguidelines.

Free NCCN Guidelines apps for iPhone, iPad, and Android devices are now available! Visit NCCN.org/apps.

About NCCN Flash Updates™

NCCN Flash Updates™ is a subscription service from NCCN that provides timely notification of updated and new information appearing in the NCCN Guidelines, the NCCN Compendium^®, and other NCCN Content.

Subscribe to NCCN Flash Updates™

Please note: 1. Third Party Content. The NCCN Content may contain content (such as figures, tables or illustrations) that NCCN licenses from third parties as displayed on NCCN Third Party Content FTP site: ftp://ftp1.nccn.org (To access: user name:content; password is NCCNcontent) (“Third Party Content”). Licensee shall be solely responsible for obtaining permissions from each such third party to use any such Third Party Content in the Permitted Works.

Access information on permissions and licensing of NCCN Content

Users may unsubscribe from Flash Updates at any time by contacting us. NOTE: The subscription fee for NCCN Flash Updates™ is non-refundable.