NCCN Guidelines for Patients
Acute Lymphoblastic Leukemia, Version 1.2017
Older Adults with Ph-negative ALL
Maintenance therapy is given to keep up (maintain)
the good results of prior treatments. The goal is to
prevent a relapse after induction and consolidation
therapy. A relapse is when leukemia cells come back
after a complete remission.
If you are not treated with an allogeneic SCT, you will
likely be treated with a maintenance chemotherapy
regimen for 2 to 3 years. Maintenance therapy drugs
are often given in lower doses and cause fewer
side effects. CNS preventive treatment can also be
given throughout this treatment phase. This regimen
may include weekly methotrexate, daily 6-MP,
monthly vincristine, and a steroid (prednisone or
dexamethasone). Methotrexate and 6-MP can affect
the liver or lead to low blood counts, and may require
dose reduction or discontinuation.
After the allogeneic SCT or after completing
consolidation and maintenance therapy, see Guide
15 for follow-up testing.