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63

NCCN Guidelines for Patients

®

:

Acute Lymphoblastic Leukemia, Version 1.2017

5

Treatment guide

Follow-up after treatment for ALL

Follow-up after treatment for ALL

Guide 15. Follow-up testing after treatment

Year Tests Timing

Year 1

• Physical exam, including testicular exam (if needed)

Every 1–2 months

• CBC with differential and liver function tests

Every 1–2 months (liver function

tests continue until normal)

• Lumbar puncture

As needed

• Echocardiogram

As needed

• Bone marrow aspiration

As needed

• If bone marrow aspiration is done, other tests may include:

Flow cytometry, cytogenetic testing, FISH, and PCR

As needed

• Cytogenetic tests (

BCR-ABL

1) for PH-postive ALL

Routine testing

Year 2

• Physical exam, including testicular exam (if needed)

Every 3–6 months

• CBC with differential

Every 3–6 months

Year 3+

• Physical exam, including testicular exam (if needed)

Every 6–12 months or as needed

• CBC with differential

Every 6–12 months or as needed

Guide 15

shows the tests that are recommended

after completing the entire treatment regimen,

including induction, consolidation, and maintenance.

Follow-up tests are given after treatment to check

how well treatment worked.

It is important for treatment to kill all of the leukemia

cells and keep them away. Doctors use follow-up

tests to look for signs of cancer return (relapse)

after treatment. These tests also check how well

your organs and body systems are working. This is

needed since ALL and its treatment can cause much

damage.

Follow-up tests

The suggested schedule of follow-up tests is shown

in Guide 15. Many of the tests used to diagnose ALL

and plan treatment are repeated during follow-up.

During the first year of follow-up, a physical exam

should be done every 1 to 2 months. The physical

exam gives your doctor an idea about your general

health. For males, it may include a testicular exam.

A CBC with differential should also be done every 1

to 2 months during the first year of follow-up. This

test will show if there is a

normal number of each

type of blood cell.