Table of Contents Table of Contents
Previous Page  22 / 88 Next Page
Information
Show Menu
Previous Page 22 / 88 Next Page
Page Background

20

NCCN Guidelines for Patients

®

:

Brain Cancer – Gliomas, Version 1.2016

2

Test and treatment overview

Cancer lab tests

Cancer lab tests

Tissue samples from surgery will be sent to a

pathologist. A pathologist is a doctor who’s an expert

in testing cells to find disease. For brain or spinal

tumors, the pathologist should be a neuropathologist.

He or she will examine the samples using a

microscope.

All lab results are recorded in a pathology report. It’s

a good idea to get a copy of your pathology report.

It’s used to plan treatment. A meeting between all

your doctors may be helpful for treatment planning

once the pathology report is finished.

Histologic typing

If cancer is present, the pathologist will study the

parts of the cancer cells to classify the disease. This

is called histologic typing. The pathology report will

state if the cancer started in the central nervous

system or elsewhere. If the cancer is a glioma, the

subtype will be noted in the report.

Molecular testing

Any of your body’s molecules that can be measured

to assess your health is known as a biomarker.

Gliomas can differ between people by which

biomarkers are present. Pathologists may conduct

molecular (aka biomarker) testing to help with

diagnosis and treatment planning. After surgery,

testing of three biomarkers is often performed if the

cancer is a glioma. These biomarkers are described

next.

1p19q co-deletion

A translocation is a switching of parts between two

chromosomes. A hallmark of oligodendrogliomas

is a translocation that results in the loss of the new

chromosome.

See Figure 4

. This marker also

occurs in many oligoastrocytomas.

The translocation occurs between chromosomes 1

and 19. When both parts of the new chromosome

Figure 4

1p19q co-deletion

A hallmark of

oligodendrogliomas is

a translocation between

chromsomes 1 and 19 that

results in deleted parts.

Copyright © 2016 National Comprehensive Cancer Network® (NCCN®).

www.nccn.org

1

p

q

1

p

q

19

p

q

19

p

q

1

p

q

1

p

q

19

p

q

19

p

q

Normal chromosomes

Switched and deleted parts