NCCN Guidelines for Patients
Brain Cancer – Gliomas, Version 1.2016
Test and treatment overview
Cancer lab tests
Cancer lab tests
Tissue samples from surgery will be sent to a
pathologist. A pathologist is a doctor who’s an expert
in testing cells to find disease. For brain or spinal
tumors, the pathologist should be a neuropathologist.
He or she will examine the samples using a
All lab results are recorded in a pathology report. It’s
a good idea to get a copy of your pathology report.
It’s used to plan treatment. A meeting between all
your doctors may be helpful for treatment planning
once the pathology report is finished.
If cancer is present, the pathologist will study the
parts of the cancer cells to classify the disease. This
is called histologic typing. The pathology report will
state if the cancer started in the central nervous
system or elsewhere. If the cancer is a glioma, the
subtype will be noted in the report.
Any of your body’s molecules that can be measured
to assess your health is known as a biomarker.
Gliomas can differ between people by which
biomarkers are present. Pathologists may conduct
molecular (aka biomarker) testing to help with
diagnosis and treatment planning. After surgery,
testing of three biomarkers is often performed if the
cancer is a glioma. These biomarkers are described
A translocation is a switching of parts between two
chromosomes. A hallmark of oligodendrogliomas
is a translocation that results in the loss of the new
See Figure 4
. This marker also
occurs in many oligoastrocytomas.
The translocation occurs between chromosomes 1
and 19. When both parts of the new chromosome
A hallmark of
a translocation between
chromsomes 1 and 19 that
results in deleted parts.
Copyright © 2016 National Comprehensive Cancer Network® (NCCN®).www.nccn.org
Switched and deleted parts