NCCN Guidelines for Patients® | Chronic Lymphocytic Leukemia

16 NCCN Guidelines for Patients ® : Chronic Lymphocytic Leukemia, 2018 2 Treatment planning Medical history | Physical exam Guide 1. Care before treatment Must haves Type of care Sometimes useful Type of care • Medical history Medical history • Hepatitis B testing Blood test • Physical exam Exam of the body • Quantitative immunoglobulins Blood test • Performance status Status of activity level • Haptoglobin Blood test • Complete blood count with differential Blood test • Reticulocyte count and direct Coombs test Blood test • Comprehensive metabolic panel Blood test • Beta-2 microglobulin Blood test • FISH for chromosomes 11, 12, 13, and 17 Blood test • LDH ( l actate d e h ydrogenase) Blood test • Karyotype Blood test • Uric acid Blood test • DNA sequencing for IGHV and TP53 Blood test • CT scan of chest, abdomen, and pelvis with contrast Imaging test • PET/CT scan Imaging test • Echocardiogram or MUGA Heart test • Bone marrow aspiration + biopsy Bone and marrow test • Pregnancy test (if you can have babies) Pregnancy test • Fertility Fertility support

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