NCCN Guidelines for Patients® | Chronic Lymphocytic Leukemia

18 NCCN Guidelines for Patients ® : Chronic Lymphocytic Leukemia, 2018 2 Treatment planning Blood tests Cell protein tests Certain protein tests may be helpful in CLL, but not for every person. CD38, CD49d, and ZAP-70 levels, for example, can provide information on CLL prognosis. However, CD38, CD49d, and ZAP-70 levels are related to the IGHV mutation. If molecular analysis to test for IGHV is not an option, your doctor may test for CD38, CD49d, and ZAP-70. The IGHV testing is preferred as the protein levels are not as reliable. Complete blood count with differential A CBC ( c omplete b lood c ount) measures the number of blood cells in a blood sample. It includes numbers of white blood cells, red blood cells, and platelets. Your blood counts may be low or high because of cancer or another health problem. It is an essential test that gives a picture of your overall health. There are several types of white blood cells in your body. A white cell differential counts the number of each type. It also checks if the counts are in balance with each other. Your doctor can learn from this test what the cause of an abnormal white blood count is. It is also used to stage the cancer and check if treatment is working. Comprehensive metabolic panel Chemicals in your blood come from your liver, bone, and other organs. A comprehensive metabolic panel often includes tests for up to 14 chemicals. The tests show if the level of chemicals are too low or high. Figure 6 Immunoglobulin (A.K.A antibody) Antibodies attach to germs so your immune system can find and destroy the germs. Normal antibodies are Y-shaped proteins made of two heavy chain proteins and two light chain proteins. Within CLL cells, the genes for making the heavy chain protein sometimes aren’t normal. Illustration Copyright © 2017 Nucleus Medical Media, All rights reserved.