NCCN Guidelines for Patients® | Chronic Lymphocytic Leukemia

28 NCCN Guidelines for Patients ® : Chronic Lymphocytic Leukemia, 2019 3  Treatment guide Review Review † † The goal of treatment is to achieve a remission and stop CLL from growing. † † The preferred first-line treatment is ibrutinib. Other options may be chemoimmunotherapy or CD20 antibody treatment. † † If first-line therapy doesn’t work or the cancer relapses, you may receive the same or a different type of treatment. Options are similar to first-line treatment. † † CLL can transform into a faster-growing cancer. Clinical trials, chemotherapy, and PD-1 antibodies may be options if this happens. † † Supportive care is an important part of your cancer care. It can help prevent life-threatening infections.