NCCN Guidelines for Patients® | Chronic Myeloid Leukemia

23 NCCN Guidelines for Patients ® : Chronic Myeloid Leukemia, 2018 Omacetaxine is the newest chemotherapy for CML. It is active against all of the mutations that make TKI not work. It is used for advanced phases of CML. Read Part 5 for more information. Omacetaxine is given as a liquid that is injected under the skin with a needle. Other chemotherapy drugs may be injected into a vein. Or, they may be given as a pill that is swallowed. Chemotherapy is given in cycles of treatment days followed by days of rest. This allows your body to recover before the next cycle. Cycles vary in length depending on which drugs are used. Often, a cycle is 14, 21, or 28 days long. If you will have chemotherapy, ask your doctor how many cycles will be given. Also ask how many days of treatment there are within a cycle. Side effects Side effects of chemotherapy depend on multiple factors. These factors include the drug type, amount taken, length of treatment, and the person. In general, side effects are caused by the death of fast- growing cells. Fast-growing cells are found in the hair follicles, gut, mouth, and blood. Death of these cells can cause low blood cell counts, not feeling hungry, nausea, vomiting, diarrhea, hair loss, and mouth sores. Most side effects appear shortly after treatment starts and will stop after treatment. However, other side effects are long-term or may appear years later. Late side effects include another type of cancer, heart disease, and problems having babies (infertility). Not all side effects of chemotherapy are listed here. Please ask your treatment team for a complete list of common and rare side effects. If a side effect bothers you, tell your treatment team. There may be ways to help you feel better. There are also ways to prevent some side effects. 3 Overview of cancer treatments Chemotherapy Supportive care Supportive care doesn’t aim to treat cancer but aims to improve quality of life. It is also called palliative care. It can address many needs. One example is treatment for physical and emotional symptoms. Supportive care can also help with treatment decisions as you may have more than one option. It can also help with coordination of care between health providers. Talk with your treatment team to plan the best supportive care for you.