NCCN Guidelines for Patients® | Chronic Myeloid Leukemia
39 NCCN Guidelines for Patients ® : Chronic Myeloid Leukemia, 2018 5 Advanced phases Review Review Additional testing is needed for advanced phases to plan the best treatment. Treatment options are based on prior treatment, mutations in CML cells, and your health. Joining a clinical trial is encouraged. TKIs are often used to treat the advanced phase. Chemotherapy or steroids may be added if in blast phase. Some people may receive an allogeneic HCT. If there is a big drop in CML cells, think about taking a TKI for 1 year. If CML cells remain high or increase, talk with your transplant doctor about treatment options.