NCCN Guidelines for Patients® | Chronic Myeloid Leukemia
50 NCCN Guidelines for Patients ® : Chronic Myeloid Leukemia, 2018 Dictionary complete blood count (CBC) A test of the number of blood cells. complete blood count (CBC) with differential A test of the number of blood cells as well as the different types of white blood cells in a sample. complete cytogenetic response (CCyR) When tests don’t find any copies of the Philadelphia chromosome. complete molecular response (CMR) No copies of the abnormal BCR-ABL1 gene are found using a very sensitive test. cytogenetics The study of chromosomes. deoxyribonucleic acid (DNA) A chain of chemicals in cells that contains genes and is bundled into long strands called chromosomes. diagnose To confirm or identify a disease or health condition. donor A person who gives his/her organs, tissues, or cells to another person. donor lymphocyte infusion (DLI) Procedure in which the patient receives white blood cells from the same person who donated blood-forming cells for the stem cell transplant. drug interaction A change in the way a drug acts or works in the body when it is taken with another drug or substance. drug resistance When cancer does not respond to a drug treatment. eosinophil A type of white blood cell that helps fight infections and has small particles (granules). fatigue Severe tiredness despite getting enough sleep that limits one’s ability to function. flow cytometry A test that looks at certain substances on the surface of cells to identify the type of cells present. fluorescence in situ hybridization (FISH) A lab test that uses special dyes to look for abnormal changes in a cell’s genes. fusion gene A gene that is made when parts of two separate genes join together. gene A set of coded instructions in cells for making new cells and controlling how cells behave. graft-versus-host disease (GVHD) A disease that occurs when transplanted blood stem cells attack a patient’s normal cells. graft-versus-leukemia (GVL) effect An attack on cancer cells by transplanted blood stem cells. granulocyte A type of white blood cell that has small particles (granules). hematologist A doctor who’s an expert in diseases of the blood. hematopoietic cell An immature blood-forming cell from which all other types of blood cells are made. Also called blood stem cell. hematopoietic cell transplant (HCT) A treatment that replaces damaged or diseased cells in the bone marrow with healthy blood-forming cells. Also called stem cell transplant. human leukocyte antigen (HLA) Special proteins on the surface of cells that help the body to tell its own cells apart from foreign cells. human leukocyte antigen (HLA) testing A blood test that finds a person’s HLA type—the unique set of proteins on the surface of cells that helps the body to tell its own cells apart from foreign cells. human leukocyte antigen (HLA) type The unique set of proteins on the surface of cells that helps the body to tell its own cells apart from foreign cells. immune system The body’s natural defense against infection and disease. International Scale (IS) A standardized scale for measuring and reporting results of a very sensitive test that measures the number of cells that have the BCR-ABL1 gene.