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28

NCCN Guidelines for Patients

®

:

Colon Cancer, Version 1.2017

3

Overview of cancer treatments

Targeted therapy

low blood cell counts, not feeling hungry, nausea,

vomiting, diarrhea, hair loss, and mouth sores.

Oxaliplatin causes a very unique side effect. It can

cause a short-lived and sometimes painful sensitivity

in areas exposed to cold. Examples of these areas

are your mouth when drinking cold liquids and your

fingers when holding a cold object. If more oxaliplatin

is used over time, loss of sensation and tingling in

fingers and toes can occur. It can take months or

years for these symptoms to resolve. You might end

up having a permanent loss of sensation in your feet

after long-term oxaliplatin-based treatment (sensory

neuropathy).

Not all side effects of chemotherapy are listed here.

Please ask your treatment team for a complete list of

common and rare side effects. If a side effect bothers

you, tell your treatment team. There may be ways to

help you feel better. There are also ways to prevent

some side effects.

Targeted therapy

Targeted therapy is a class of drugs that stops the

action of molecules that help cancer cells grow. It is

less likely to harm normal cells than chemotherapy.

Targeted therapy for colon cancer targets either the

VEGF (

v

ascular

e

ndothelial

g

rowth

f

actor) or EGFR

(

e

pidermal

g

rowth

f

actor

r

eceptor) pathway.

Targeted therapy used for colon cancer is listed in

Guide 3

. Many of these are also called biologic

therapies because they are antibodies. Antibodies

are Y-shaped proteins. Some are made by your body.

The ones used for colon cancer were made in a lab.

Targeted therapies are briefly described next. Some

side effects are listed. Ask your treatment team for

a full list of common and rare side effects. In Parts 4

through 6, information on who should receive these

drugs is provided.

Guide 3. Targeted therapy

Generic (chemical) name

Brand name (sold as)

Bevacizumab

Avastin

®

Cetuximab

Erbitux

®

Panitumumab

Vectibix

®

Ramucirumab

Cyramza

®

Regorafenib

Stivarga

®

Ziv-aflibercept

Zaltrap

®