NCCN Guidelines for Patients
Esophageal Cancer, Version 1.2016
Treatment guide: Adenocarcinoma
The regimen for preoperative chemotherapy is:
• 5-FU and cisplatin.
Regimens for perioperative chemotherapy are:
• 5-FU and cisplatin,
• Epirubicin, cisplatin, and 5-FU*,
• Epirubicin, oxaliplatin, and 5-FU*,
• Epirubicin, cisplatin, and capecitabine*, and
• Epirubicin, oxaliplatin, and capecitabine*.
*These perioperative regimens are not advised
by most NCCN experts.
Doctors call chemoradiation given to try to cure
cancer “definitive chemoradiation.” It is an option
if the tumor is rated T4b. Even if you are healthy
enough for surgery, these tumors can’t be first treated
Chemotherapy regimens for definitive chemoradiation
• Cisplatin and 5-FU (or capecitabine)
• Oxaliplatin and 5-FU (or capecitabine)
• Paclitaxel and carboplatin
• Cisplatin with docetaxel or paclitaxel
• Irinotecan and cisplatin
• Paclitaxel and fluoropyrimidine (5-FU or
Not approved or decline surgery
Guide 19 also lists options for people unable to have
surgery. Chemoradiation to try to cure the cancer is
an option if chemotherapy will do more good than
harm. Regimens for definitive chemotherapy are
listed in the left column.
If you are unable to have chemotherapy, supportive
care is advised. This may include radiation therapy
to prevent or treat symptoms caused by cancer.
Supportive care is addressed later in this chapter in