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NCCN Guidelines for Patients


Esophageal Cancer, Version 1.2016

Guide 23

lists the treatment options for cancer that

returned during follow-up care. The return of cancer

is called a recurrence. Options are based on where

the cancer returned and prior treatment. Cancer that

returns near to where the esophagus is (or was) is

called a locoregional recurrence. Cancer that returns

in distant sites from the esophagus is a metastatic


Locoregional recurrence

If you had an esophagectomy only, options include

chemoradiation, surgery, chemotherapy, and

supportive care. The recommended chemotherapy for

chemoradiation is:

Preferred regimens

• Cisplatin and 5-FU (or capecitabine)

• Oxaliplatin and 5-FU (or capecitabine)

• Paclitaxel and carboplatin

Other regimens

• Cisplatin with docetaxel or paclitaxel

• Irinotecan and cisplatin

• Paclitaxel and fluoropyrimidine (5-FU or


If you had chemoradiation only, options depend on if

you can have surgery. If you can, an esophagectomy

is advised. Otherwise, you can receive supportive


Metastatic recurrence

Supportive care is advised for metastatic cancer.

Supportive care is addressed in the next section

Advanced cancer



Treatment guide: Adenocarcinoma

Return of cancer