NCCN Guidelines for Patients® | Lung Cancer - Non-Small Cell Lung Cancer

55 NCCN Guidelines for Patients ® : Lung Cancer – Non-Small Cell, 2018 Ramucirumab Ramucirumab attaches to VEGF receptors on the outside of endothelial cells. This blocks VEGF from attaching. No growth signals caused by VEGF are started. Ramucirumab is given by infusion. It takes 60 minutes to receive the full dose. Ramucirumab is always given with chemotherapy. It is given every two weeks on the first day of chemotherapy. Common side effects of ramucirumab are high blood pressure and diarrhea. Serious side effects include bleeding, blood clots, tears in your gut, abnormal passage between body parts, and slow wound healing. Very rarely, brain damage occurs. Don’t take bevacizumab if pregnant, trying to get pregnant, or breastfeeding. Other targets Although rare, there are other biomarkers of lung cancer for which there are treatments. These treatments are approved for lung or other cancers but still need more research. Such treatments include ado-trastuzumab for HER2. Cabozantinib and vandetanib target RET. In addition to targeting ALK and ROS1, crizotinib targets MET. 5 Overview of cancer treatments Targeted therapy Complementary and alternative medicine CAM ( c omplementary and a lternative m edicine) is a group of treatments that aren’t often given by doctors. There is much interest today in CAM for cancer. Many CAMs are being studied to see if they are truly helpful. Complementary medicines are treatments given along with usual medical treatments. While CAMs aren’t known to kill cancer cells, they may improve your comfort and well- being. Two examples are acupuncture for pain management and yoga for relaxation. Alternative medicine is used in place of usual medicine. Some alternative medicines are sold as cures even though they haven’t been proven to work in clinical trials. If there was good proof that CAMs or other treatments cured cancer, they would be included in this book. It is important to tell your treatment team if you are using any CAMs. They can tell you which CAMs may be helpful and which CAMs may limit how well medical treatments work.