NCCN Guidelines for Patients® | Lung Cancer - Non-Small Cell Lung Cancer

57 NCCN Guidelines for Patients ® : Lung Cancer – Non-Small Cell, 2018 What to expect PD-1 and PD-L1 inhibitors are given by infusion. Durvalumab and nivolumab are given every 2 weeks for 60 minutes. Pembrolizumab is given every 3 weeks for 30 minutes. Atezolizumab is given every 3 weeks for 60 minutes Side effects Most people have fewer side effects with immunotherapy than chemotherapy. Common side effects for immunotherapy include feeling tired despite sleep. It is also common to feel constipated, nauseated, and not hungry. You may have muscle or bone pain. Any organ can become inflamed while taking immunotherapy. This is rare but can cause severe side effects involving the lung, gut, liver, kidney, hormones, or skin. Don’t take immunotherapy if you are pregnant, trying to get pregnant, or breastfeeding. It may harm your baby. Not all side effects of immunotherapy are listed here. Please ask your treatment team for a complete list of common and rare side effects. If a side effect bothers you, tell your treatment team. There may be ways to help you feel better. There are also ways to prevent some side effects. Clinical trials One of your treatment choices may be to join a clinical trial. Joining a clinical trial is strongly supported. NCCN believes that you will receive the best management in a clinical trial. New tests and treatments aren’t offered to the public as soon as they’re made. They first need to be studied. A clinical trial is a type of research that studies a test or treatment in people. Clinical trials study how safe and helpful tests and treatments are for people. When found to be safe and helpful, they may become tomorrow’s standard treatment. Because of clinical trials, the tests and treatments in this book are now widely used to help people with lung cancer. Future tests and treatments that may have better results will depend on clinical trials. New tests and treatments go through a series of clinical trials. These trials aim to ensure they’re safe and work. Without clinical trials, there is no way to know if a test or treatment is safe or helpful. Clinical trials have four phases. Some examples of the four phases of treatment are: † † Phase I trials aim to find the safest and best dose of a new drug. Another aim is to find the best way to give the drug with the fewest side effects. These trials often involve about 20 people. † † Phase II trials assess if a drug works for a specific type of cancer. These trials often involve 20 to 100 people. † † Phase III trials compare a new drug to a standard treatment head-to-head. These trials often involve hundreds or thousands of people. † † Phase IV trials test drugs approved by the U.S. FDA ( F ood and D rug A dministration) to learn more about side effects with long-term use. Joining a clinical trial has benefits. First, you’ll have access to the most current cancer care. However, please note that it is unknown how well new treatments will work, if at all. Second, you will receive the best management of care. Third, the results of your treatment—both good and bad—will be carefully tracked. Fourth, you may help other people who will have cancer in the future. 5 Overview of cancer treatments Clinical trials

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