NCCN Guidelines for Patients® | Lung Cancer - Non-Small Cell Lung Cancer

89 NCCN Guidelines for Patients ® : Lung Cancer – Non-Small Cell, 2018 7 Metastatic cancer Biomarkers not present or unknown Guide 26. Treatment for adenocarcinoma, large cell, unknown types First-line treatment Performance scores What are the options? 0 or 1 • Platinum-based chemotherapy • Bevacizumab + platinum-based chemotherapy • Pembrolizumab + chemotherapy 2 • Chemotherapy 3 or 4 • Supportive care Maintenance treatment Maintenance type What are the options? Continuation • Bevacizumab • Pemetrexed • Bevacizumab + pemetrexed • Gemcitabine Switch • Pemetrexed Either type • Watch and wait Next-in-line treatment Performance scores What are the options? 0 or 1 or 2 • Nivolumab (preferred) • Pembrolizumab (preferred) • Atezolizumab (preferred) • Docetaxel • Pemetrexed • Gemcitabine • Ramucirumab + docetaxel 3 or 4 • Supportive care

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