NCCN Guidelines for Patients® | Lung Cancer - Non-Small Cell Lung Cancer

90 NCCN Guidelines for Patients ® : Lung Cancer – Non-Small Cell, 2018 Squamous cell carcinoma Guide 27 lists treatments for squamous cell carcinoma. Treatment options are based on performance status. First-line treatment You may be treated with chemotherapy if your performance score is between 0 and 2. Your doctor will choose a regimen based on how well it will stop cancer growth compared to how harmful it could be. A performance score of 3 or 4 suggests that chemotherapy will be too harmful. Therefore, the best supportive care is advised. Supportive care aims to treat the symptoms caused by the cancer. Maintenance treatment First-line treatment may stop the cancer from getting worse. In this case, you may stay on some of your first-line treatments. This is called continuation maintenance. Another option is changing to a medicine that you didn’t take as a first-line treatment. 7 Metastatic cancer Biomarkers not present or unknown Guide 27. Treatment for squamous cell carcinoma First-line treatment Performance scores What are the options? 0 or 1 • Platinum-based chemotherapy 2 • Chemotherapy 3 or 4 • Supportive care Maintenance treatment Maintenance type What are the options? Continuation • Gemcitabine Switch • Docetaxel Either type • Watch and wait Next-in-line treatment Performance scores What are the options? 0 or 1 or 2 • Nivolumab (preferred) • Pembrolizumab (preferred) • Atezolizumab (preferred) • Docetaxel • Gemcitabine • Ramucirumab + docetaxel 3 or 4 • Supportive care

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