NCCN Guidelines for Patients® | Myelodysplastic Syndromes

15 NCCN Guidelines for Patients ® : Myelodysplastic Syndromes, 2018 2 Testing for MDS Medical history Treatment planning starts with testing. This section describes the tests that are used to check for and confirm (diagnose) MDS. These tests also help doctors plan treatment. This information can help you use the Treatment guide in Part 5. It may also help you know what to expect during testing. Medical history Your medical history includes any health events in your life and any medicines you’ve taken. A medical history is needed for treatment planning. See Guide 1 for a full list of the tests that are recommended before treatment for MDS. Your doctor will ask about illnesses, injuries, and health problems that you have had. This includes any low blood cell counts (cytopenias) you have had. Your doctor will also ask about prior infections, abnormal bleeding, and the number of blood transfusions you’ve had. Your doctor will also ask about any symptoms you’ve had that may be due to MDS. This information may affect which cancer treatment is best for you. It may help to make a list of old and new medicines while at home to bring to your doctor’s office. Guide 1. Tests used to diagnose MDS Needed for most patients May be needed for some patients • Medical history and physical exam • Copper level • CBC ( c omplete b lood c ount) with differential • HIV ( h uman i mmunodeficiency v irus) testing • LDH ( l actate d e h ydrogenase) • HLA ( h uman l eukocyte a ntigen) typing • Reticulocyte count • Flow cytometry • Blood smear • FISH ( f luorescence i n s itu h ybridization) • Serum EPO ( e rytho po ietin) • Molecular testing • Iron, ferritin, folate, and vitamin B12 • Check for certain congenital (from birth) medical conditions • Assess for thyroid problems • Bone marrow biopsy and aspiration • Cytogenetic testing

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