NCCN Guidelines for Patients® | Myelodysplastic Syndromes

Contents 7
How to use this book 8
1: Myelodysplastic syndromes 9
The blood cells 10
MDS basics 11
Types of MDS 12
Symptoms of MDS 14
Review 15
2: Testing for MDS 16
Medical history 17
Physical exam 18
Blood tests 18
Bone marrow biopsy and aspiration 20
Genetic tests 21
Review 23
3: Prognostic scoring and risk groups 24
Prognostic factors 25
Prognostic scoring and risk groups 25
Risk groups: lower risk versus higher risk 27
Review 28
4: Overview of cancer treatments 29
Supportive care 30
Chemotherapy 33
Immunotherapy 34
Immunomodulators 35
Targeted therapy 35
Hematopoietic cell transplant 37
Donor lymphocyte infusion 38
Clinical trials 40
Review 41
5: Treatment guide 42
Treatment options 43
Lower-risk MDS with anemia 44
Lower-risk MDS without anemia 47
Higher-risk MDS 48
Treatment for anemia 51
6: Making treatment decisions 55
It’s your choice 56
Questions to ask your doctors 56
What’s my diagnosis and prognosis? 57
What are my options? 58
What does each option require of me? 59
What is your experience? 60
Deciding between options 61
Websites and resources 62
Glossary 63
Dictionary 64
Acronyms 69
NCCN Panel Members for Myelodysplastic Syndromes 72
NCCN Member Institutions 73
Index 74

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