NCCN Guidelines for Patients® | Melanoma

41 NCCN Guidelines for Patients ® : Melanoma, 2018 4  Overview of melanoma treatments Immunotherapy Side effects of pembrolizumab and nivolumab The most common side effects of these drugs are diarrhea, skin rash, itchy skin, fatigue, nausea, vomiting, diarrhea, and bone, joint, and/or muscle pain. Some of these side effects are more common for one drug than the other. Not all side effects are listed here. Be sure to discuss this with your doctor. Ipilimumab Ipilimumab is an immunotherapy drug used as systemic therapy for melanoma. It is a monoclonal antibody—a type of immune system protein made in a lab. It works by removing the “brakes” on the immune system and is often called an "immune checkpoint locker." This boosts the immune system’s response against melanoma cells in the body. Ipilimumab is a liquid that is injected into a vein. It may be given at high doses for adjuvant treatment of melanoma in the lymph nodes that has been surgically removed. Adjuvant treatment is additional treatment given after surgical removal of the tumor to kill any remaining cancer cells elsewhere in the body. Guide 3. Immunotherapy drugs as systemic therapy for melanoma Generic name Brand name (sold as) Route given Aldesleukin; IL-2 ( i nter l eukin-2) Proleukin ® Liquid injected into a vein Interferon alfa-2b Intron ® A Liquid injected into a vein or under the skin Ipilimumab Yervoy ® Liquid injected into a vein Nivolumab Opdivo ® Liquid injected into a vein Peginterferon alfa-2b Sylatron™ Liquid injected under the skin Pembrolizumab Keytruda ® Liquid injected into a vein Guide 4. Immunotherapy drugs as local therapy for melanoma Generic name Brand name (sold as) Route given BCG ( B acillus C almette- G uérin) Live TICE ® BCG Liquid injected into the tumor Imiquimod Aldara ® Cream that is spread onto the tumor Interferon alfa-2b Intron ® A Liquid injected into the tumor IL-2; Aldesleukin Proleukin ® Liquid injected into the tumor T-VEC ( t alimogene laherparep vec ) Imlygic™ Liquid injected into the tumor

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