87 NCCN Guidelines for Patients ® : Melanoma, 2018 Dictionary genetic test Tests of the instructions in cells for making and controlling cells. gland An organ that makes fluids or chemicals the body needs. groin The area of the body where the thigh meets the lower belly area (abdomen). histologic subtype Grouping of cancer types based on cancer cell qualities. hormones Chemicals in the body that activate cells or organs. imaging tests Tests that make pictures (images) of the inside of the body. imiquimod cream A drug made as a cream that boosts the immune system (the body’s natural defense against disease) response against skin cancer cells. immune cells Cells that are part of the body’s natural defense against infection and disease. immune system The body’s natural defense against infection and disease. immunotherapy Treatment that activates or boosts the body’s natural defense against disease (immune system) to fight cancer. incisional biopsy Surgery that removes part of the skin tumor or abnormal- looking area (lesion) to test for cancer cells. in situ In its original place. intestine The organ that eaten food passes through after leaving the stomach. in-transit metastases Cancer that has spread into lymph vessels near the first tumor but not into lymph nodes (groups of special disease- fighting cells). in-transit recurrence Cancer that has come back after treatment in lymph vessels near the first tumor but not in lymph nodes (groups of special disease-fighting cells). isolated limb infusion/perfusion Anticancer drugs are given directly into an arm or leg in a way that they don’t reach or affect the rest of the body. kidneys A pair of organs that filter blood and remove waste from the body through urine. lactate dehydrogenase (LDH) A substance found in the blood that is involved in energy production in cells. lentigo maligna melanoma The slowest growing type of melanoma; it starts in sun- exposed skin and is commonly mistaken for a sunspot. lesion An area of abnormal tissue that has been damaged by disease or injury. limited metastatic disease Cancer that has spread to one or a few distant sites. liver An organ that removes waste from the blood. local anesthesia Medicine that results in a temporary loss of feeling in a small area of the body to prevent pain in that area during a test or procedure. local melanoma Cancer cells haven’t spread beyond the skin near the first (primary) tumor. local metastasis The spread of cancer cells from the first tumor to a nearby site. local recurrence Cancer that has come back after treatment in or near the same place as the first tumor. A satellite recurrence is a type of local recurrence. local therapy Treatment that affects cells in one small, specific part of the body only, such as the tumor and nearby area.