89 NCCN Guidelines for Patients ® : Melanoma, 2018 Dictionary nodal basin A group or cluster of lymph nodes (groups of special disease-fighting cells) located close to one another in a certain area of the body such as near a tumor. node-negative Cancer cells are not found in lymph nodes (groups of special disease-fighting cells located throughout the body). node-positive Cancer cells are found in lymph nodes (groups of special disease-fighting cells located throughout the body). nodular melanoma A type of melanoma that has a dome shape and may grow more quickly into the second layer of skin (dermis) than other melanomas. non-melanoma skin cancer Cancer of the skin that starts in cells other than melanocytes (cells that give skin its color). nonmetastatic recurrence Cancer that has come back after treatment but has not spread to parts of the body far away from the first tumor. observation A period of scheduled follow-up testing to watch for signs of cancer spread (metastasis) or return (recurrence). palliative treatment Treatment given to relieve symptoms caused by cancer or side effects caused by cancer treatment. Also called supportive care. pathologic stage A rating of the extent of melanoma in the body based on tests of lymph nodes and other tissue removed during surgical treatment. pathologist A doctor who’s an expert in testing cells and tissue to find disease. pathology report A document with information about cancer cells and tissue that were removed from the body and examined with a microscope for disease. pelvis The body area between the hipbones. peripheral margin status Presence or absence of cancer cells in the normal-looking tissue around the sides of a tumor removed during surgery. persistent melanoma Cancer not completely removed or destroyed by treatment; persistent melanoma is found in or right next to the surgical scar where the first melanoma was removed. Also called true local scar recurrence. physical exam A review of the body by a health expert for signs of disease. positive margins There are cancer cells in the normal-looking tissue around the edge of the tumor removed during surgery. positron emission tomography (PET) scan A test that uses radioactive material to see the shape and function of organs and tissues inside the body. primary treatment The main treatment used to rid the body of cancer. primary tumor The first mass of cancer cells in the body. prognosis The likely or expected course and outcome of a disease. protein A chain of chemical compounds important to every cell in the body. punch biopsy Removal of tissue using a sharp, hollow, round-shaped knife in order to test it for disease. radiation therapy Use of high-energy rays to destroy cancer cells. radiotracer Matter with energy that is put into the body to make pictures clearer. recurrence The return of cancer after treatment. regimen A treatment plan that specifies the dosage, schedule, and duration of treatment.