90 NCCN Guidelines for Patients ® : Melanoma, 2018 Dictionary regional lymph node recurrence Cancer that has come back after treatment in lymph nodes (groups of special disease-fighting cells) near the first melanoma. regional lymph nodes Groups of special disease-fighting cells located near the tumor. regional melanoma Cancer cells have spread from the first tumor to nearby lymph vessels, lymph nodes (groups of special disease- fighting cells), and/or nearby skin. regional therapy Treatment with cancer-killing drugs directed to a specific area of the body such as an arm or leg. rheumatoid arthritis An autoimmune disorder that causes pain, swelling, and stiffness in the joints. risk evaluation and mitigation strategy (REMS) program A program to monitor and manage serious side effects (unplanned physical or emotional effects) of cancer treatments. risk factor Something that increases the chance of getting a disease. satellite metastases Small melanoma tumors (satellites) in the skin near the first (primary) tumor. satellite recurrence Cancer that came back after treatment and formed small melanoma tumors in lymphatic channels in the skin deep within the scar site or just outside of the surgical scar of the first tumor. scar A permanent mark on the skin after an injury or surgery. self-exam of skin A careful review of your own skin for abnormal-looking spots that may be signs of skin cancer. sentinel lymph node The first lymph node (groups of special disease-fighting cells) to which lymph, and possibly a cancer cell, travels after leaving the first (primary) tumor. sentinel lymph node biopsy Surgery to remove the first lymph node to which lymph, and possibly a cancer cell, travels after leaving the first (primary) tumor. shave biopsy Surgery that removes a thin tissue sample from the top of a tumor to test for cancer cells. side effect An unplanned or unwanted physical or emotional condition caused by treatment. single agent The use of one drug. skin biopsy Removal of a sample of tissue from the skin to test for disease. skin exam A careful review of the skin to check for abnormal-looking spots that may be signs of skin cancer. spleen An organ to the left of the stomach that helps protect the body against disease. staging The process of rating and describing the extent of cancer in the body. stereotactic radiosurgery (SRS) A type of radiation therapy that delivers a high dose of radiation to a small, specific area. subcutaneous Below the skin. sun protection factor (SPF) A rating of the level of protection sunscreen products provide against the UV rays from the sun. superficial At, on, or near the top or surface. superficial spreading melanoma The most common type of melanoma; it grows slowly and spreads from a mole. supportive care Treatment given to relieve the symptoms caused by cancer or side effects caused by cancer treatment. Also called palliative treatment.