NCCN Guidelines for Patients® | Myeloproliferative Neoplasms

12 NCCN Guidelines for Patients ® : Myeloproliferative Neoplasms, 2018 1 MPN basics Review a blood vessel in the lung by a blood clot is called a pulmonary embolism. A blood clot in an artery to the brain can cause a stroke. Other cancers MPNs can transform. ET and PV can evolve into MF. Some MPNs change into MDS. Sometimes, MPNs may become a fast-growing cancer called AML ( a cute m yeloid l eukemia). The likelihood to transform into AML differs among the MPN subtypes. MF is the most likely to transform but very rarely happens. ET is the least likely to become AML. Potentially shorter lifespan MPNs are slow-growing cancers. Many people can live for years with the proper treatment. However, people with a MPN may have a shorter lifespan compared to their peers. People with MF typically have shorter lifespans than people with ET or PV. Review † † Most blood cells are formed in bone marrow. Blood (hematopoietic) stem cells are the cells from which all blood cells are formed. † † MPNs are a group of rare blood cancers. They are cancers derived from blood-forming stem cells. † † The three classic MPNs are essential thrombocythemia, polycythemia vera, and primary myelofibrosis. † † People may have symptoms for a long time before they learn they have a MPN. † † MPNs can lead to serious health conditions, such as blood clots and leukemia. A rare disease isn’t so rare when you have one. – Jean Survivor, Polycythemia vera “