NCCN Guidelines for Patients® | Myeloproliferative Neoplasms

14 NCCN Guidelines for Patients ® : Myeloproliferative Neoplasms, 2018 2 Testing for MPN Medical history | Symptom survey Your doctor may think you have a blood cancer. Part 2 describes the tests used to diagnose MPN. It also describes tests used for treatment planning. Medical history Your medical history includes any health events and medicines you’ve taken in your life. You will be asked about illnesses, injuries, health conditions, and more. It may help to make a list of old and new medications while at home to bring to your doctor’s office. Your doctor will also want to know if you’ve had blood transfusions. Another important issue is the health of your blood-flowing (cardiovascular) system. Tell your doctor if you have high blood pressure or diabetes. Your doctor will also want to know about your diet, exercise level, and smoking history. Also, tell your doctor if you’ve had blood clots or abnormal bleeding. Some cancers and other health conditions can run in families. Thus, your doctor will ask about the medical history of your blood relatives. You doctor may ask about the health of your siblings, your parents and their siblings, and your grandparents and their siblings. Be prepared to tell who in your family has had what diseases and at what ages. A medical history is needed for diagnosis and treatment planning. See Guide 1 for a complete list of care that is advised prior to treatment. Some tests are for everyone with MPN while others are for a select group. Symptom survey Sometimes MPNs cause symptoms. Such symptoms can be assessed with a survey called the MPN-SAF ( M yelo p roliferative N eoplasm S ymptom A ssessment F orm). This survey lists 18 symptoms. Each symptom is rated on a scale from 0 to 10. Higher scores point to worse symptoms. This form is used by doctors to assess symptom burden and plan treatment. Your symptoms will also be tracked during treatment. More information on symptom tracking for each classic MPN is in Parts 3 through 5. Guide 1. Tests for MPN Test name • Medical history • MPN-SAF survey • Physical exam • CBC with differential • Comprehensive metabolic panel • EPO and iron levels • Bone marrow aspiration and biopsy • BCR-ABL1 testing • Bone marrow cytogenetics • Molecular testing for JAK2 mutations and maybe MPL and CALR mutations • HLA typing for some people • Coagulation tests for some people

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