NCCN Guidelines for Patients® | Myeloproliferative Neoplasms

16 NCCN Guidelines for Patients ® : Myeloproliferative Neoplasms, 2018 2 Testing for MPN Blood tests Uric acid Certain phases of MPNs produce many bone marrow cells. In turn, uric acid levels increase. High uric acid levels can cause gout and kidney stones. Testing for uric acid is done to assess if you have excess uric acid in your blood (hyperuricemia). Liver function tests Your liver is an organ in the upper right side of your abdomen. It does many important jobs, such as remove toxins from your blood. Liver function tests assess for chemicals that are made or processed by the liver. With MPN, there may be abnormal results if the cancer is in the bone or liver. EPO and iron levels EPO ( e rythro po ietin) and iron levels can impact red blood cells. EPO is a hormone made by your kidneys. It is needed to make red blood cells. You may have low counts of red blood cells. Testing may reveal that low EPO levels—instead of cancer—are the cause. EPO testing also helps to diagnose PV. Features of PV include high red blood cell counts and hemoglobin level. These high amounts suppress EPO levels. In PV, blood tests usually show low EPO levels. Iron is a mineral that is part of hemoglobin. Low levels of iron can cause hemoglobin levels to drop (anemia). In turn, iron-deficiency anemia can cause high counts of platelets. Iron testing may help reveal that iron deficiency—instead of cancer—is causing increased platelets. Low iron levels also occur in PV. The supply of iron is used to create red blood cells. Thus, in contrast to iron-deficiency anemia, PV causes high red blood cell counts and hemoglobin levels. A diagnosis was made because of migraines due to a high platelet count and following blood work and a bone marrow biopsy confirmed ET. – Antje Survivor, Essential thrombocythemia “