NCCN Guidelines for Patients® | Myeloproliferative Neoplasms

20 NCCN Guidelines for Patients ® : Myeloproliferative Neoplasms, 2018 2 Testing for MPN Coagulation tests | Review Coagulation tests Your body stops bleeding by turning blood into a gel-like form. This process is called coagulation. Proteins, called coagulation factors, are needed for this process. Coagulation tests assess how well these proteins work and sometimes protein levels. A sample of your blood is needed for testing. Coagulation tests are advised for certain people. This test may be done if you have 1) abnormal bleeding; 2) increased platelets, especially over 1 million; 3) an enlarged spleen; or 4) a surgery scheduled that may cause major bleeding. It’s important to learn if your blood coagulates normally. Some health problems limit coagulation. One example is acquired VWD ( v on W illebrand d isease). “Acquired” means the disorder was not passed down from your parents. Acquired VWD occurs more often with ET than with other MPNs. It usually occurs when platelet counts are very high. The high platelet counts limit how well the von Willebrand proteins clot. Review † † A medical history is a report of all health events in your lifetime. It will include questions about your family’s health, too. † † Your doctor will examine your body for signs of disease. He or she will touch parts of your body to see if anything feels abnormal. † † Blood tests assess the parts of your blood. Your doctor will use the blood results to help decide if and what type of disease is present. † † A bone marrow exam removes bone and marrow for testing. † † Genetic tests assess for abnormal changes in chromosomes and genes. Results can help your doctor identify a disease and plan treatment. † † HLA typing is needed if you will receive a transplant of stem cells from a donor. † † Coagulation tests on your blood may be needed. Family and online education and support sites (MPN-NET) have been vital to my emotional stability and critical to my understanding of PV. – Susan Survivor, Polycythemia vera “