NCCN Guidelines for Patients® | Myeloproliferative Neoplasms

23 NCCN Guidelines for Patients ® : Myeloproliferative Neoplasms, 2018 3 Essential thrombocythemia Initial treatment Initial treatment There are two treatment goals for ET. The first is to prevent serious health conditions caused by ET. The second goal is to relieve symptoms. In general, people with ET have a normal or near-normal lifespan. Younger women with ET may want to have a baby. Before getting pregnant, it may help to meet with a high-risk obstetrician and a blood specialist (hematologist). These doctors can tell you what health care you will need during pregnancy. Guide 2 lists the treatment options for ET. Options are based on your chance for having a blood clot. Some blood clots can cause a heart attack, stroke, or serious breathing problems. If pregnant, blood clots may harm you and your baby. Your doctor will assess whether you are at very low, low, intermediate, or high risk. † † Very low risk describes people who are 60 years of age or younger, don’t have a JAK2 mutation, and never had a blood clot. † † Low risk describes people who are 60 years of age or younger, have a JAK2 mutation, and never had a blood clot. † † Intermediate risk describes people who are older than 60 years of age, don’t have a JAK2 mutation, and never had a blood clot. † † High risk describes people who 1) have had a blood clot or 2) are older than 60 years and have a JAK2 mutation. Guide 2. Initial ET treatment by risk group What are the options? Very Low Low Intermediate High • Assess for secondary health problems • Reduce cardiovascular risk factors (ie, high blood pressure, diabetes, smoking) • Aspirin for vascular symptoms • Observation instead of aspirin • Cytoreductive treatment (ie, hydroxyurea, interferons, anagrelide)

RkJQdWJsaXNoZXIy MTE3MTE1