NCCN Guidelines for Patients® | Myeloproliferative Neoplasms

43 NCCN Guidelines for Patients ® : Myeloproliferative Neoplasms, 2018 of marrow and blood cells may be normal or slightly low. There must be none or only minor bone marrow fibrosis (Grade 0 or 1). Related cancers are excluded. You must not have another type of MPN. You also must not have MDS or another myeloid neoplasm. A common mutation may be present. JAK2 , CALR , and MPL mutations are common. If no common mutation is present, there may be another known marker. Otherwise, there is no other molecular cause for myelofibrosis. Last, one or more of the following 4 conditions may be present. You may have anemia that isn’t caused by another health condition. Your white blood cell count may be high. Your LDH level may be high. Your spleen may be enlarged. Overt PMF Your bone marrow must have typical features of PMF. It must contain many abnormal megakaryocytes. There must also be higher-grade bone marrow fibrosis. Related cancers are excluded. You must not have another type of MPN. You also must not have MDS or another myeloid neoplasm. There is usually a mutation in JAK2 , CALR , or MPL genes. If no common mutation is present, there may be another known marker. Otherwise, there is no other molecular cause for myelofibrosis. Last, one or more of the following 5 conditions must be present: 1) anemia that isn’t caused by another condition; 2) a high white blood cell count; 3) a high LDH level; 4) an enlarged spleen; and 4) immature blood cells in blood that should only be in bone marrow. Post-ET myelofibrosis This diagnosis requires that you have had ET with higher-grade bone marrow fibrosis. Two of the following 5 conditions must be present: 1) anemia that isn’t caused by another condition; 2) immature blood cells in blood that should only be in bone marrow; 3) a high LDH level; 4) an enlarged spleen; and 5) weight loss or night sweats caused by MF. Post-PV myelofibrosis This diagnosis requires that you have had PV with higher-grade bone marrow fibrosis. Two of the following 4 conditions must be present: 1) anemia that isn’t caused by another condition; 2) immature blood cells in blood that should only be in bone marrow; 3) an enlarged spleen; and 4) weight loss or night sweats caused by MF. 5 Myelofibrosis Diagnosis

RkJQdWJsaXNoZXIy MTE3MTE1