NCCN Guidelines for Patients® | Multiple Myeloma

11 NCCN Guidelines for Patients ® : Multiple Myeloma, 2018 1 Multiple myeloma M-proteins Figure 4 Antibodies made by a plasma cell versus a myeloma cell Antibodies are y-shaped proteins that are made by normal plasma cells and by myeloma cells. Normal antibodies are made of two heavy protein chains and two light protein chains. Different types of antibodies are needed to fight different types of germs and infections. People with healthy plasma cells make all these different types of antibodies. But, myeloma cells make only one type of antibody—called M-protein. Myeloma cells also tend to make too many light chains. Figure 3 Plasma versus myeloma cell growth Normal cells grow and divide to make new cells as the body needs them. Normal cells die when they are old or damaged. New cells are then made to replace the old. Leukemia cells don’t die when they should. Instead, they continue to grow and divide to make more and more copies of themselves. Illustration Copyright © 2017 Nucleus Medical Media, All rights reserved. www.nucleusinc.com Illustration Copyright © 2017 Nucleus Medical Media, All rights reserved. www.nucleusinc.com

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