37 NCCN Guidelines for Patients ® : Multiple Myeloma, 2019 3 Myeloma treatments Review Review Surgery and radiation therapy are used when there is a single mass of myeloma cells—called a solitary plasmacytoma. Chemotherapy drugs kill fast-growing cells, including cancer cells and normal cells. Targeted therapy drugs target a specific or unique feature of cancer cells. A stem cell transplant replaces damaged or diseased cells in the bone marrow with healthy blood stem cells. An autologous stem cell transplant uses your own blood stem cells. An allogeneic stem cell transplant uses blood stem cells from another person, called a donor. Adjunctive treatment for the symptoms of myeloma and side effects of myeloma treatment is very important. A clinical trial studies a test or treatment to see how safe it is and how well it works.